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Journal of Timely Topics in Clinical Immunology | Volume 2
July 26-28, 2018 | Moscow, Russia
Immunology
11
th
Annual Congress on
Bortezomib increases risk of herpes zoster infection in multiple myeloma
Ying Li
1
, Juan Li
1
and
Qingping Wu
2
1
Hospital of Sun-yat-sen University, China
2
Guangdong Institute of Microbiology, China
Aims:
To find out the characteristic manifestations of herpes
zoster (HZ) infections in multiple myeloma (MM) patients
who received bortezomib, and analyze the risk factors for HZ
infection in these MM patients.
Methods:
Retrospectively compared the HZ infections in 142
cases of MM who received bortezomib and 86 cases receiving
traditional chemotherapies to found out the characteristic
manifestations in the bortezomib group.
Results:
MM receiving bortezomib were more susceptive
to HZ infection at the early stage of the treatment (P<0.01).
Compared to the traditional regimens, bortezomib-base
regimens brought higher HZ infection risk (P=0.047) and severe
and atypical manifestations to MM patients (P=0.028). Worse
still, boterzomib-treated patients needed more time to recover
from HZ infections (P=0.008). And the IgG type, 6 months after
bortezomib treatment and lymphocytes counts<1.0×109/L
were independent risk factors of herpes zoster infection
(P<0.01).
Conclusions:
MM patients receiving bortezomib were more
vulnerable to HZ infection. And once infected, they were slower
in recovery and had to delay their chemotherapy plan (P=0.48).
As a result, to those MM with risk factors of HZ infection,
preventive antivirus and immuno enhancer are suggested.
Speaker Biography
Ying Li holds the position of assistant fellow in Guangdong Institute of Microbiology,
the state key laboratory of applied microbiology Southern China. Ying Li is thirty-
two yrs old and have majored in clinical medicine, hematology and immunology in
Sun-yat-sen University since 2004. She became Attending physician of hematology
in 2016. In 2017, she joined the Guangdong Institute of Microbiology, the state key
laboratory of applied microbiology Southern China as assistant fellow and continue
her study on microbiome, immunology and hematology. Ying Li has published
eight SCI manuscripts and three books about multiple myeloma and hematology.
e:
liying@gdim.cn