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Journal of Timely Topics in Clinical Immunology | Volume 2

July 26-28, 2018 | Moscow, Russia

Immunology

Annual Congress on

Inflammation and Vitamin D: The Infection Connection

Meg Mangin

Chronic Illness Recovery, USA

nflammation is believed to be a contributing factor in many

chronic diseases. The influence of vitamin D deficiency

on inflammation is being explored but studies have not

demonstrated a causative effect. Low serum 25(OH)D is also

found in healthy persons exposed to adequate sunlight. Despite

increased vitamin D supplementation inflammatory diseases

are increasing. The current method of determining vitamin

D status may be at fault. The level of 25(OH)D doesn’t always

reflect the level of 1,25(OH)2D. Assessment of bothmetabolites

often reveals elevated 1,25(OH)2D, indicating abnormal

vitamin D endocrine function. Some authorities now believe

that low 25(OH)D is a consequence of chronic inflammation

rather than the cause. Research points to a bacterial etiology

pathogenesis for an inflammatory disease process which results

in high 1,25(OH)2D and low 25(OH)D. Immunotherapy, directed

at eradicating persistent intracellular pathogens, corrects

dysregulated vitamin D metabolism and resolves inflammatory

symptoms. This article reviews vitamin D’s influence on the

immune system, examines the myths regarding vitamin D

photosynthesis, discusses ways to accurately assess vitamin

D status, describes the risks of supplementation, explains

the effect of persistent infection on vitamin D metabolism

and presents a novel immunotherapy which provides

evidence of an infection connection to inflammation.

Speaker Biography

Meg Mangin, R.N. is the Executive Director of Chronic Illness Recovery. She has presented

at many conferences, including Days of Molecular Medicine in Karolinska, the International

Conference on Autoimmunity in Porto, Portugal, the American Society of Hypertension

Meeting, Enabling Future Pharma, Perspectives in Rheumatic Diseases, Immunology

Summit, International Lyme Society, American Association of Family Practitioners and the

18th Vitamin DWorkshop. She is the co-author of a chapter in the textbook Vitamin D: New

Researchandtheleadauthoroftheground-breakingreviewarticleInflammationandvitamin

D: the infection connection published in the October 2014 issue of Inflammation Research.