Opinion Article - Journal of Cell Biology and Metabolism (2023) Volume 5, Issue 4
The self-administration of methamphetamine in rats is reduced by glial cell modulators.
Department of Pharmacology & Toxicology, Virginia Commonwealth University, USA
- *Corresponding Author:
- Patrick Snider
Department of Pharmacology & Toxicology
Virginia Commonwealth University
Received:26-Jul-2023, Manuscript No. AACBM-23-109371; Editor assigned:28-Jul-2023, PreQC No. AACBM-23-109371(PQ); Reviewed:11-Aug-2023, QC No. AACBM-23-109371; Revised:16-Aug-2023, Manuscript No. AACBM-23-109371(R); Published:23-Aug-2023, DOI:10.35841/ aacbm-5.4.161
Citation: Snider P. The self-administration of methamphetamine in rats is reduced by glial cell modulators. J Cell Biol Metab. 2023;5(4):161
In the intricate landscape of the human brain, glial cells stand as the unsung heroes, often overshadowed by their more illustrious counterparts, the neurons. Yet, their significance in the realm of neuroscience cannot be overstated. Glial cells, also known as neuroglia or glia, are a diverse and vital group of non-neuronal cells that play an essential role in supporting and maintaining the intricate functioning of the nervous system. These remarkable cells, once thought to be mere scaffolding for neurons, have emerged as key players in brain development, communication, and overall brain health .
The addiction to methamphetamine still poses a serious threat to world health, thus novel techniques are required to comprehend its neurological basis and consider available treatment options. Glial cells, formerly considered to be just supporting players in the brain, have now come to light as playing a crucial role in determining addictive behaviors, according to recent study. Glial cell modulators in particular have shown promise in reducing methamphetamine self-administration in rat studies. This article explores the fascinating results of these investigations, highlighting the expanding knowledge of the role of glial cells in addiction and its implications for potential therapeutic approaches .
Strong stimulant methamphetamine impacts the brain's reward pathways, which causes obsessive drug seeking and use. Animal models of addiction are extremely useful for studying addiction and examining prospective therapies because the repetitive self-administration of methamphetamine in these animals closely resembles the addictive behaviors seen in humans.Neurons dominated the study of glial cells in neuroscience for a long time. Nevertheless, scientific developments have shown that glial cells, such as astrocytes and microglia, actively take part in a number of brain processes, such as neurotransmission, neuroinflammation, and synaptic plasticity. These non-neuronal cells are now understood to interact intricately with neurons and affect the environment of the entire brain .
The use of glial cell modulators in the setting of methamphetamine addiction has produced promising outcomes. For instance, it has been demonstrated that particular anti-inflammatory drugs or glial cell inhibitors, which target glial cell function, decrease methamphetamine self-administration in rat models. Researchers have successfully reduced the drug's reinforcing effects by glial cell activity modulation, potentially opening up new treatment options for addiction.Exciting opportunities for addiction study and care are presented by the expanding body of data that glial cells play a role in methamphetamine addiction. We are getting closer to creating novel therapies for people battling with methamphetamine addiction as we better understand how glial cell modulators affect self-administration behaviors in rat models. Although the road ahead may be difficult, the opportunity to lessen the burden of addiction and enhance lives makes this research endeavor even more attractive and essential , .
- Bachtell R, R Hutchinson M, Wang X, et al. Targeting the toll of drug abuse: The translational potential of toll-like receptor 4. Neur Dis Drug Tar. 2015;14(6):692-9.
- Reissner KJ, Brown RM, Spencer S, et al. Chronic administration of the methylxanthine propentofylline impairs reinstatement to cocaine by a GLT-1-dependent mechanism. Neuropsychopharmacol. 2014;39(2):499-506.
- Pickens CL, Airavaara M, Theberge F, et al. . Neurobiology of the incubation of drug craving. Trends Neurosci. 2011;34(8):411-20.
- Parsegian A, See RE. Dysregulation of dopamine and glutamate release in the prefrontal cortex and nucleus accumbens following methamphetamine self-administration and during reinstatement in rats. Neuropsychopharmacol. 2014;39(4):811-22.
- Reichel CM, Schwendt M, McGinty JF, et al. Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5. Neuro Psycho Pharmacol. 2011;36(4):782-92.