Journal of Pharmacology and Therapeutic Research

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Commentary - Journal of Pharmacology and Therapeutic Research (2023) Volume 7, Issue 5

Targeted Therapies and Personalized Pharmacology

Jonathon Askie *

Department of Pharmacological and Pharmaceutical Sciences,University of Houston, USA

*Corresponding Author:
Jonathon Askie
Department of Pharmacological and Pharmaceutical Sciences,University of Houston, USA
E-mail: askiejonathon@cougarnet.uh

Received: 04-sept-2023, Manuscript No. AAJPTR-23-112137; Editor assigned: 05-sept-2023, PreQC No. AAJPTR-23-112137; Reviewed:18-sept-2023, QC No. AAJPTR-23-112137; Revised:23-sept-2023, Manuscript No. AAJPTR-23-112137 (R); Published:30-sept-2023, DOI:10.35841/ aajptr -7.5.164

Citation: Askie J. Targeted therapies and personalized pharmacology. J Pharmacol Ther Res. 2023; 7(5):164

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In the ever-evolving landscape of medicine, the paradigm of healthcare has shifted from a one-size-fits-all approach to a more tailored and precise methodology. At the forefront of this transformation are targeted therapies and personalized pharmacology, two interconnected concepts that have revolutionized the way we approach disease treatment. These innovations not only enhance therapeutic outcomes but also embody the true essence of patient-centered care, marking a new era in medical practice [1].

Targeted therapies represent a groundbreaking shift in how we combat diseases, especially those that were once considered challenging to treat. Unlike traditional treatments that affect both healthy and diseased cells, targeted therapies are designed to act specifically on molecular alterations unique to diseased cells. This precision minimizes collateral damage to healthy tissues, resulting in fewer side effects and improved quality of life for patients [2].

The foundation of targeted therapies lies in the understanding of genetic and molecular aberrations driving diseases. Advances in genomics have illuminated the genetic mutations, overexpressed proteins, and dysregulated pathways that characterize various conditions, including cancer. Armed with this knowledge, researchers develop drugs that selectively inhibit or modulate these disease-driving factors. For instance, tyrosine kinase inhibitors in cancer treatment are designed to thwart the activity of specific molecules that drive tumor growth [3].

While targeted therapies focus on specific disease mechanisms, personalized pharmacology takes customization to a deeper level by considering the individual patient's genetic makeup, physiology, and unique response patterns. The central tenet of personalized pharmacology is recognizing that each patient may react differently to a given treatment due to genetic variations that influence drug metabolism, efficacy, and adverse reactions [4].

Pharmacogenomics, a cornerstone of personalized pharmacology, studies how genetic variations impact a person's response to drugs. By identifying specific genetic markers, clinicians can predict how a patient will metabolize a drug and whether it will be effective or cause adverse effects. This knowledge enables healthcare providers to tailor treatment regimens, selecting the most suitable medication and dosage for each patient [5].


Targeted therapies and personalized pharmacology embody a profound shift in the way we approach healthcare. They embody the ideals of precision medicine, offering tailored treatments that consider both the disease's molecular nuances and the patient's genetic makeup. As technology continues to advance and our understanding of disease mechanisms deepens, the potential for more effective, efficient, and patient-centric treatments becomes increasingly apparent. The trajectory of medical progress is now intertwined with these innovative approaches, holding the promise of not just treating diseases, but truly improving lives and fostering a future where healthcare is as unique as the individuals it serves


  1. Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes. The lancet. 2017 Jun 3;389(10085):2239-51.
  2. Indexed at , Google Scholar , Cross Ref

  3. Zafar A, Wang W, Liu G, et al. Molecular targeting therapies for neuroblastoma: Progress and challenges. Res. Rev. 2021;41(2):961-1021.
  4. Indexed at , Google Scholar , Cross Ref

  5. van den Bulk J, Verdegaal EM, de Miranda NF. Cancer immunotherapy: broadening the scope of targetable tumours. Open Biol. 2018;8(6):180037.
  6. Indexed at , Google Scholar , Cross Ref

  7. Sadee W, Wang D, Hartmann K, et al.Pharmacogenomics: Driving personalized medicine. Rev. 2023;75(4):789-814.
  8. Indexed at , Google Scholar , Cross Ref

  9. Xie F, Chan JC, Ma RC. Precision medicine in diabetes prevention, classification and management. J Diabetes Investig. 2018;9(5):998-1015.
  10. Indexed at , Google Scholar , Cross Ref

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