Perspective - Integrative Neuroscience Research (2023) Volume 6, Issue 3
Neurological Consequences of Chronic Traumatic Encephalopathy (CTE): Insights into Pathophysiology and Clinical Implications.
George Lindsay *
Department of Psychology, Institute of Neurosciences, Hospital Clinic, Barcelona, Spain
- *Corresponding Author:
- George Lindsay
Department of Psychology,
Institute of Neurosciences, Hospital Clinic,
Received: 29-May-2023, Manuscript No. AAINR-23-101805; Editor assigned: 01-Jun-2023, PreQC No. AAINR-23-101805(PQ); Reviewed: 15-Jun-2023, QC No. AAINR-23-101805; Revised: 20-Jun-2023, Manuscript No. AAINR-23-101805; Published: 27-Jun-2023, DOI:10.35841/aainr-6.3.147
Citation: Lindsay G. Neurological consequences of chronic traumatic encephalopathy: Insights into pathophysiology and clinical implications. Integr Neuro Res. 2023;6(3):147
Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative condition associated with repeated head injuries, particularly in individuals engaged in contact sports and military combat. This article provides a comprehensive review of the current understanding of CTE, including its pathophysiology, clinical manifestations, diagnostic criteria, and implications for patient management. The article also highlights on-going research efforts aimed at improving our understanding of CTE and developing potential therapeutic interventions .
Pathophysiology of CTE
This section explores the underlying pathophysiological mechanisms of CTE, including the accumulation of abnormal protein aggregates, such as tau protein, throughout the brain. It discusses the impact of these proteinopathies on neuronal health, neuroinflammation, and synaptic dysfunction, elucidating the complex cascade of events that contribute to the neurodegenerative process in CTE.
Here, we delve into the clinical manifestations associated with CTE, which often manifest years or even decades after the initial head injury. The article outlines the common symptoms, including cognitive impairment, mood disturbances, behavioral changes, and motor dysfunction, and discusses the challenges in diagnosing CTE during a patient's lifetime. The recently proposed diagnostic criteria and staging systems are also presented, emphasizing the need for comprehensive clinical evaluation and integration of other diagnostic modalities, such as neuroimaging and biomarkers.
This section explores the risk factors and susceptibility factors associated with the development and progression of CTE. It examines genetic predisposition, age of exposure, and the cumulative effects of repetitive head injuries. Additionally, it highlights the role of other factors, such as sex, playing position, and coexisting neurodegenerative conditions, in influencing the clinical course of CTE .
The article discusses the current approaches to managing patients with CTE, focusing on symptom management, supportive care, and lifestyle modifications. It also emphasizes the importance of a multidisciplinary approach involving neurologists, neuropsychologists, psychiatrists, and other healthcare professionals. Furthermore, this section explores potential prevention strategies, including injury prevention initiatives and rule modifications in contact sports.
In this section, we provide an overview of the on-going research efforts aimed at better understanding CTE and its underlying mechanisms. This includes advancements in neuroimaging techniques, identification of biomarkers, and preclinical studies exploring potential therapeutic targets. The section concludes by discussing future directions for research, including the development of disease-modifying treatments and strategies for early detection and intervention .
Chronic Traumatic Encephalopathy (CTE) represents a significant public health concern due to its association with repetitive head injuries. This article provides a comprehensive review of the current understanding of CTE, emphasizing its pathophysiology, clinical manifestations, diagnostic criteria, and management strategies. While significant progress has been made, further research is necessary to advance our understanding of CTE and develop effective treatments to improve the lives of those affected by this debilitating condition
- Wilson L, Stewart W, Horton L, et al. The chronic and evolving neurological consequences of traumatic brain injury. Lancet Neurol. 2017;16(10):813-25.
- Hay J, Johnson VE, Smith DH, et al. Chronic traumatic encephalopathy: The neuropathological legacy of traumatic brain injury. Annu Rev Pathol: Mech Dis. 2016;11:21-45.
- Jordan BD. Chronic traumatic encephalopathy and other long-term sequelae. CONTIN Lifelong Learn Neurol. 2014;20(6):1588-604.
- Nowinski CJ, Bureau SC, Buckland ME, et al. Applying the Bradford Hill criteria for causation to repetitive head impacts and chronic traumatic encephalopathy. Front Neurol. 2022;13:938163.
- Zygun DA, Kortbeek JB, Fick GH, et al. Non-neurologic organ dysfunction in severe traumatic brain injury. Crit Care Med. 2005;33(3):654-60.