Journal of Brain and Neurology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (202) 780-3397

Short Communication - Journal of Brain and Neurology (2025) Volume 8, Issue 2

Neurodegenerative disorders: Challenges and advances in research

Carolina Gubert*

Department of Neuroscience, University of Melbourne, Australia

*Corresponding Author:
Carolina Gubert
Department of Neuroscience
University of Melbourne, Australia
E-mail: caroligubert@florey.edu.au

Received: 01-May-2025, Manuscript No. AAJBN-25-171400; Editor assigned: 05-May-2025, Pre QC No. AAJBN-25-171400 (PQ); Reviewed: 17-May-2025, QC No. AAJBN-25-171400; Revised: 24-May-2025, Manuscript No. AAJBN-25-171400 (R); Published: 31-May-2025, DOI: 10.35841/aajbn-8.2.191

Citation: Gubert C. Neurodegenerative disorders: Challenges and advances in research. J Brain Neurol. 2025;8(2):191

Visit for more related articles at Journal of Brain and Neurology

Introduction

Neurodegenerative disorders represent a group of chronic, progressive conditions characterized by the gradual loss of structure or function of neurons, ultimately leading to their death. These disorders, which include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS), impose a significant burden on individuals, families, and healthcare systems worldwide. The complexity of these conditions lies not only in their clinical manifestations but also in their multifactorial causes, involving genetics, environment, and lifestyle. [1].

Alzheimer’s disease is the most common neurodegenerative disorder, marked by memory loss, cognitive decline, and behavioral changes. The accumulation of beta-amyloid plaques and tau protein tangles in the brain are central pathological features, yet the exact mechanisms driving disease progression remain elusive. Parkinson’s disease, on the other hand, primarily affects motor function due to the degeneration of dopaminergic neurons in the substantia nigra, leading to tremors, stiffness, and difficulty with movement. Both conditions highlight the intricate relationship between molecular changes and clinical outcomes. [2].

Huntington’s disease and ALS further emphasize the devastating impact of neurodegeneration. Huntington’s, caused by a genetic mutation in the HTT gene, results in uncontrolled movements, emotional disturbances, and cognitive decline. ALS, often referred to as Lou Gehrig’s disease, is characterized by the degeneration of motor neurons, leading to progressive muscle weakness, paralysis, and eventually respiratory failure. These disorders not only challenge scientific understanding but also demand compassionate care strategies to address patient and caregiver needs.[3].

Research into the mechanisms of neurodegenerative disorders has expanded rapidly, focusing on pathways such as oxidative stress, mitochondrial dysfunction, neuroinflammation, and protein misfolding. Advances in neuroimaging, molecular biology, and genetics have provided valuable insights, yet effective treatments remain limited. Current therapies largely manage symptoms rather than halt or reverse disease progression. This highlights the urgent need for innovative approaches that target disease mechanisms more precisely. [4].

Promising strategies include gene therapy, stem cell transplantation, and novel pharmacological agents designed to reduce protein aggregation or modulate immune responses in the brain. Additionally, lifestyle factors such as exercise, diet, and cognitive stimulation are being investigated for their potential role in prevention and disease modification. The integration of personalized medicine, artificial intelligence, and biomarker discovery is paving the way toward earlier diagnosis and tailored interventions. [5].

Conclusion

The growing prevalence of neurodegenerative disorders due to global aging underscores the importance of sustained research, healthcare innovation, and public awareness. While challenges remain in unravelling the complexities of these diseases, recent scientific advances offer hope for improved outcomes in the future. By combining biomedical research with supportive care and preventive measures, society can move closer to mitigating the burden of neurodegenerative disorders and enhancing the quality of life for those affected.

References

  1. Cebral JR, Castro MA, Soto O, et al. Blood-flow in the Circle of Willis from magnetic resonance data. J Eng Math. 2003;47(4):369-86.

    2. Indexed at, Google Scholar, Cross Ref

  2. Atabek HB. Wave propagation through a viscous fluid contained in a tethered, initially stressed, orthotropic elastic tube. J Biophys. 1968;8:626-49.

    3. Indexed at, Google Scholar, Cross Ref

  3. Broderick J, Brott T, Kothari R, et al. The Greater Cincinnati/Northern Kentucky Stroke Study: Preliminary first-ever and total incidence rates of stroke among blacks. Stroke. 1998;29:415-421.

    4. Indexed at, Google Scholar, Cross Ref

  4. Kim BJ, Kang GH, Ahn SH, et al. Magnetic Resonance Imaging in Acute Ischemic Stroke Treatment. J Stroke. 2014;16(3):131-45.

    5. Indexed at, Google Scholar, Cross Ref

  5. Kumamaru KK, Hoppel BE, Mather RT, et al. CT Angiography: Current Technology and Clinical Use. Radiol Clin North Am. 2010;48(20):213-35.

    6. Indexed at, Google Scholar, Cross Ref

Get the App