Microbiology: Current Research

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Perspective - Microbiology: Current Research (2022) Volume 6, Issue 5

Microbial co-infections and antibiotic resistance in patients with COVID-19

Israt Hossain*

Department of Microbiology, University of Dhaka, Dhaka, Bangladesh

*Corresponding Author:
Mbamalu ON
Department of Microbiology
University of Dhaka, Dhaka, Bangladesh
E-mail: hossain.Israt@du.ac.bd

Received: 30-Aug-2022, Manuscript No. AAMCR-22-77448; Editor assigned: 02-Sep-2022, Pre QC No. AAMCR-22-77448(PQ); Reviewed: 16-Sep-2022, QC No. AAMCR-22-77448; Revised: 21-Sep-2022, Manuscript No. AAMCR-22-77448 (R); Published: 29-Sep-2022, DOI: 10.35841/aamcr-6.5.125

Citation: Hossain I. Microbial co-infections and antibiotic resistance in patients with COVID-19. J Micro Curr Res. 2022;6(5):125

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The novel coronavirus infectious disease 2019 (Coronavirus), brought about by extreme intense respiratory disorder Covid 2 (SARS-CoV-2) has damaged the entire world with the continuous crushing pandemic. A plenty of microbial spaces including infections (other than SARS-CoV-2), microscopic organisms, archaea and parasites have developed together, and collaborate in complex sub-atomic pathogenesis alongside SARS-CoV-2. In any case, the association of other microbial co-microorganisms and hidden atomic systems prompting exploitative disease in fundamentally sick Coronavirus patients has yet not been broadly evaluated. Albeit, the rate of co-diseases could depend on 94.2% in research facility affirmed Coronavirus cases, the destiny of co-diseases among SARS-CoV-2 tainted has frequently relies upon the harmony between the host's defensive resistance and immunopathology. Prevalently distinguished co-microorganisms of SARS-CoV-2 are microbes, for example, Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Acinetobacter baumannii, Legionella pneumophila and Clamydia pneumoniae followed by infections including flu, Covid, rhinovirus/enterovirus, parainfluenza, metapneumovirus, flu B infection, and human immunodeficiency infection. The cross-talk between co-microorganisms (particularly lung microbiomes), SARS-CoV-2 and host is a significant variable that eventually builds the trouble of finding, treatment, and prognosis of COVID-19.


COVID-19, SARS-CoV-2, Microbial co-infections, Molecular pathogenesis.


The novel Covid infectious disease 2019 (Coronavirus) is a quickly contagious pneumonia-like illness brought about by the SARS-CoV-2 which arose in Wuhan, China in December 2019, and is at present coursing all through the world. The positive-sense wrapped RNA infection (SARS-CoV-2) is hereditarily not the same as the recently referred to Covids, for example, SARS-CoV-1 and Center East respiratory condition Covid (MERS-CoV). Following its most memorable flareup inChina, this fearsome infection has arisen as quite possibly of the deadliest human microbe over the most recent hundred years after the Spanish Influenza in 1918-1920 [1]. The SARS-CoV-2 contamination has turned into a general wellbeing challenge around the world, and hence, the World Wellbeing Association has pronounced this sickness as a general wellbeing crisis of global concern. The lethal flareups of SARS in 2003 and MERS in 2012, with case casualty pace of 9.6% and 34.4%, separately were effectively held in six months or less. The Coronavirus illness impacted all out 217 nations and domains until April 7, 2021, and in excess of 133,688,126 cases have been affirmed all around the world with 2,901,038 passing’s. Consequently, this rapidly spreading Coronavirus pandemic features the basic requirement for fast advancement of immunizations and antiviral medicines to lessen the quantity of hospitalizations and passing’s by this troubling microorganism [2].

Co-disease alludes to the simultaneous contamination of a cell or host by two or numerous microbe species or potentially strains, though, super infection is a situation where one microorganism taints the host some time before contamination constantly microbe. For both of these cases, the destiny of the tainted host frequently relies upon a harmony between the host's defensive invulnerability and immunopathology. The widespread inescapability or frequency of co-disease among people is obscure, however being typical, some of the time surprisingly normal. Co-diseases might happen by different irresistible specialists of viral, bacterial, archaeal and parasitic beginning, and seem to happen at the same time with the underlying beginning of sickness [3].

Co-contaminations and super infections are normal in numerous respiratory viral irresistible illnesses. Bacterial co-diseases can essentially expand the death rate in patients tainted with any popular diseases. Beforehand, bacterial codiseases were likewise revealed in MERS-CoV patients getting serious consideration. The co-disease of the SARS-CoV-2 with different microorganisms is a vital variable in Coronavirus pathogenesis that might entangle the exact finding, treatment, forecast of Coronavirus, and even increment the death rates. Clinical preliminaries and metagenomic examinations demonstrated the co-presence of other infections, microscopic organisms, archaea and parasites with SARS-CoV-2 in Coronavirus patients. Around half of the patients who passed on from Coronavirus had optional bacterial diseases which further heighten the pathophysiological movement of Coronavirus. Better comprehension of co-diseases in Coronavirus is basic for the powerful understanding administration, treatment and regulation of SARS-CoV-2 [4]. It is accordingly, important to fortify the examination of the co-disease in Coronavirus patients. Besides, in regards to Coronavirus a few issues, for example, valuable techniques to forestall sickness spread, assortment of fitting clinical examples, transmission course, popular elements and viable medication therapies are still generally obscure. Be that as it may, the chance of co-diseases with other respiratory microbes including microscopic organisms, archaea, infections and parasites are not yet obviously comprehended. The relationship of these optional microbes to causing co-diseases ought to be a significant worry for the clinician in the administration of Coronavirus cases. The arising irresistible sicknesses part of the Places for Infectious prevention and Anticipation supported testing for other respiratory microorganisms, recommending that proof of one more disease could help the assessment of patients with potential Coronavirus without any generally accessible quick testing for SARS-CoV-2 [5].


Co-diseases with different microorganisms are generally found in SARS-CoV-2 tainted patients that altogether impacts the seriousness and death paces of Coronavirus. The Coronavirus co-diseases are related with numerous spaces of microorganisms including infections, microbes, organisms and archaea. Albeit the particular atomic occasions of co-pathogenesis in SARS-CoV-2 pathophysiology is yet obscure, the co-tainting microorganisms might partake to harm the respiratory aviation route, cell misfortune, cup cell hyperplasia, change bodily fluid discharge, diminished ciliary beat recurrence, capability and freedom, decreased oxygen trade, and harm the safe immune system.


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