Gynecology and Reproductive Endocrinology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (629)348-3199

Perspective - Gynecology and Reproductive Endocrinology (2023) Volume 7, Issue 2

Mechanism and Functional excrescencies of ovarian development in human body

John Wang *

Department of Gynaecologic Oncology, West Virginia University, Morgantown, USA

*Corresponding Author:
John Wang
Department of Gynaecologic Oncology
West Virginia University
Morgantown, USA.

Received: 22-Feb-2023, Manuscript No. AAGGS-23-91288; Editor assigned: 24-Feb-2023, PreQC No. AAGGS-23-91288 (PQ); Reviewed:10-Mar-2023, QC No. AAGGS-22-91288; Revised:14-Mar-2023, Manuscript No. AAGGS-23-91288 (R); Published: 21-Mar-2023, DOI:10.35841/2591-7994-7.2.136

Citation: Wang J. Mechanism and functional excrescencies of ovarian development in human body. Gynecol Reprod Endocrinol. 2023;7(2):136

Visit for more related articles at Gynecology and Reproductive Endocrinology


 An ovarian tubercle is a fluid- filled sac within the ovary. Frequently they beget no symptoms. Sometimes they may produce bloating, lower abdominal pain, or lower reverse pain. The maturity of excrescencies is harmless. However, it may beget severe pain, if the tubercle either breaks open or causes wringing of the ovary. This may affect in puking or feeling faint and indeed beget head pangs. Utmost ovarian excrescencies are related to ovulation, being either follicular excrescencies or corpus lutein excrescencies. Other types include excrescencies due to endometriosis, desmoids excrescencies and cyst adenomas. Numerous small excrescencies do in both ovaries in polycystic ovary pattern (PCOS).


Ovarian tubercle, Body temperature, Hormone, Menopause.


Pelvic seditious complaint may also affect in excrescencies. Infrequently, excrescencies may be a form of ovarian cancer. Opinion is accepted by pelvic examination with an ultrasound or other testing used to gather farther details. Frequently, excrescencies are simply observed overtime. However, specifics similar as paracetamol (acetaminophen) or ibuprofen may be used, if they beget pain. Hormonal birth control may be used to help farther excrescencies in those who are constantly affected. Still, substantiation doesn't support birth control as a treatment of currentcysts.However, get larger and look unusual, if they don't go down after several months. Although ovarian excrescencies generally do in cases with natural lipoid adrenal hyperplasia (CLAH), the medium of development remains to be determined. To clarify the pathogenesis of the ovarian excrescencies, endocrinological examinations were performed in cases with CLAH [1]. 

The rudimentary body temperature wasn't biphasic in any case. Rudimentary LH situations were high in all CLAH cases and markedly responded to LH- releasing hormone in two cases. Urinary gonadotropin analysis revealed repetitious LH surges in the menstrual cycles of the CLAH cases. No increase in the urinary pregnanediol suggested anovulation in all cases and bilateral ovarian excrescencies were set up in two of the subjects. Examination of the Star gene revealed a frame shift mutation 840delA at codon 238, a gibberish mutation Q258X at codon 258, a homozygotes mutation at Q258Xand an emulsion heterozygotes mutation with 251insG and Q258X [2].

Functional excrescencies

Functional excrescencies are the most common type of ovarian tubercle and are not complaint- related. They do as a result of ovulation (the release of an egg from the ovary). These excrescencies can be a sign that your ovaries are performing as they should. Functional excrescencies generally shrink over time, generally within 60 days, without specific treatment [3].

Follicular excrescencies: A small sac in your ovary, called a follicle, releases an egg each month as part of your menstrual cycle. A follicular tubercle forms when the follicle does not release an egg. Rather, the follicle fills with fluid and grows bigger.

Corpus lutein excrescencies: After the follicle releases an egg, it forms a hormone- producing group of cells called the corpus lutein. A tubercle forms when fluid collects in the corpus lutein, causing it to grow. Excrescencies that develop as part of the menstrual cycle and are generally inoffensive and short- lived; these are the most common type of ovarian tubercle. Pathological ovarian excrescencies – excrescencies that do due to abnormal cell growth; these are much less common. Each month during your menstrual cycle, a follicle (tubercle) grows on your ovary. The follicle is where an egg is developing. The follicle makes the oestrogen hormone. This hormone causes normal changes of the uterine filling as the uterus prepares for gestation. When the egg matures, it's released from the follicle. This is called ovulation. Still, the fluid stays in the follicle and forms a tubercle, if the follicle fails to break open and release an egg. This is called a follicular tubercle [4].

 Another type of tubercle occurs after an egg has been released from a follicle. This is called a corpus lutein tubercle. This type of tubercle may contain a small quantum of blood. This tubercle makes progesterone and oestrogen hormones. Ovarian excrescencies are more common in the travail times between puberty and menopause. The condition is less common after menopause. Taking fertility medicines frequently causes the development of multiple follicles (excrescencies) in the ovaries. These excrescencies most frequently go down after a woman's period, or after a gestation [5].


Functional ovarian excrescencies aren't the same as ovarian excrescences or excrescencies due to hormone- related conditions similar as polycystic ovary pattern. Conclusions we concluded that the development of ovarian excrescencies may be deduced from continued anovulation in CLAH cases. Elevated LH situations may be explained by increased perceptivity of the anterior pituitary to circulating oestrogen.


  1. Anifandis G, Sutovsky P, Turek PJ, et al. Bioethics in human embryology: the double-edged sword of embryo research. Syst Biol Reprod Med. 2022;68(3):169-79.
  2. Indexed at, Google Scholar, Cross Ref

  3. Camboni A, Cacciottola L, Chiti MC, et al. P-483 Improving in vitro culture of isolated human ovarian primordial-primary follicles by adding adipose derived stem cells. Hum Reprod. 2022;37:107-454.
  4. Indexed at, Google Scholar, Cross Ref

  5. Cheng H, Wang Z, Cui L, et al. Opportunities and challenges of the human microbiome in ovarian cancer. Front Oncol. 2020;10:163.
  6. Indexed at, Cross Ref

  7. Fayazmanesh A, Nasehi M, Vaezi G, et al. The Effect of Roaccutane on Development of Ovarian Follicles and Uterine Changes in Adult NMRI Mice Strain. Arch adv Biosci. 2021;12(2):1-9.
  8. Indexed at, Google Scholar, Cross Ref

  9. Su F, Anantharamaiah GM, Palgunachari MN, et al. Bovine HDL and dual domain HDL-mimetic peptides inhibit tumor development in mice. J Cancer Res Ther. 2020;8(1).
  10. Indexed at, Google Scholar, Cross Ref

Get the App