Archives of General Internal Medicine

Reach Us +1 (202) 780-3397

Mini Review - Archives of General Internal Medicine (2023) Volume 7, Issue 5

Investigating the use of bioidentical oestrogens in hormone replacement therapy.

Gail Irvin*

Department of Biochemistry, Stellenbosch University, Matieland, South Africa

*Corresponding Author:
Gail Irvin
Department of Biochemistry
Stellenbosch University
Matieland, South Africa

Received: 28-Sept-2023, Manuscript No. AAAGIM-23-117257; Editor assigned: 02-Oct-2023, PreQC No. AAAGIM-23-117257 (PQ); Reviewed:16-Oct-2023, QC No. AAAGIM-23-117257; Revised:23-Oct-2023 (R), Manuscript No. AAAGIM-23-117257; Published: 30-Oct-2023, DOI:10.35841/aaagim-7.5.199

Citation: Irvin G. Department of Biochemistry, Stellenbosch University, Matieland, South Africa. Arch Gen Intern Med. 2023;7(5):199

Visit for more related articles at Archives of General Internal Medicine


Hormone Replacement Therapy (HRT) has been a vital tool in managing the symptoms of menopause and addressing hormonal imbalances. Over the years, traditional hormone replacement therapy has used synthetic hormones, raising questions about its safety and effectiveness. In response to these concerns, bioidentical hormones have gained popularity as an alternative, promising a more natural approach to hormone therapy. In this article, we delve into the world of bioidentical estrogens, investigating their use in hormone replacement therapy and addressing the key questions surrounding their safety, effectiveness, and benefits[1].

Bioidentical estrogens, as the name suggests, are chemically identical to the hormones naturally produced by the human body. They are derived from plant sources, typically soy or yam, and are synthesized to match the molecular structure of endogenous estrogen closely. This molecular similarity is believed to be a key factor in reducing potential risks and side effects associated with hormone therapy. One of the significant advantages of bioidentical estrogens is that they can be customized to the individual's specific hormonal needs. This allows for a more tailored approach to hormone replacement therapy, potentially resulting in better symptom relief and overall well-being[2].

The safety of bioidentical estrogens is a topic of ongoing debate and research. Advocates argue that because these hormones are identical to those produced by the body, they may carry a lower risk of side effects and complications. However, long-term studies on the safety of bioidentical estrogens are still limited[3].

A potential concern with bioidentical hormones is the lack of standardized regulation and quality control. Unlike traditional HRT, which is regulated by the FDA, bioidentical hormones are often compounded on an individual basis by compounding pharmacies, which may vary in terms of quality and consistency[4].

Bioidentical hormone therapy is often marketed as a more personalized approach to hormone replacement. Healthcare providers who support its use often conduct thorough assessments of a patient's hormonal balance and create a treatment plan tailored to their specific needs. This individualized approach is appealing to many women seeking a more personalized solution to their menopausal symptoms[5].


Bioidentical estrogens have stirred considerable interest in the realm of hormone replacement therapy, offering a potentially more natural and individualized approach to managing menopausal symptoms. While they have shown promise in providing effective symptom relief, questions regarding safety and regulation remain. As with any medical decision, it is essential to consult with a qualified healthcare provider who can help you weigh the risks and benefits and make an informed choice that aligns with your health and wellness goals. The investigation into bioidentical estrogens continues, and ongoing research may provide more clarity on their long-term safety and effectiveness.


  1. Deleruyelle LJ. Menopausal Symptom Relief and Side Effects Experienced by Women Using Compounded Bioidentical Hormone Replacement Therapy and Synthetic Conjugated Equine Estrogen and/or Progestin Hormone Replacement Therapy, Part 2. Int J Pharm Comp. 2016;20(6):447-54.
  2. Indexed at, Google Scholar

  3. Perkins MS, Louw-du Toit R, Africander D. A comparative characterization of estrogens used in hormone therapy via estrogen receptor (ER)-α and-β. J Steroid Biochem Mol Biol. 2017;174:27-39.
  4. Indexed at, Google Scholar, Cross Ref

  5. Conaway E. Bioidentical hormones: An evidence-based review for primary care providers. Int J Osteopath Med. 2011;111(3):153-64.
  6. Indexed at, Google Scholar, Cross Ref

  7. Holtorf K. The bioidentical hormone debate: Are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?. Postgrad Med. 2009;121(1):73-85.
  8. Indexed at, Google Scholar, Cross Ref

  9. Perkins M, Louw-du Toit R, Africander D. Bioidentical hormones used in Hormone Replacement Therapy: Implications for breast cancer.
  10. Google Scholar

Get the App