Rapid Communication - Journal of Molecular Oncology Research (2023) Volume 7, Issue 5
In mice, the reaction to azoxymethane is significantly worsened by the deletion of the functioning gastrin gene.
Mary Fausto *
Department of Pathology, University of Washington, Seattle, Washington
- *Corresponding Author:
- Mary Fausto
Department of Pathology
University of Washington
Received:28-Aug-2023, Manuscript No. AAMOR-23- 112362; Editor assigned:31-Aug-2023, PreQC No. AAMOR-23- 112362 (PQ); Reviewed:14-Sep-2023, QC No. AAMOR-23- 112362; Revised:20-Sep-2023, Manuscript No. AAMOR-23- 112362 (R); Published:27-Sep-2023, DOI:10.35841/ aamor-7.5.197
Citation: Fausto M. In mice, the reaction to azoxymethane is significantly worsened by the deletion of the functioning gastrin gene. J Mol Oncol Res. 2023;7(5):197
Carcinogenesis, also known as the formation of cancer, is a complicated and sophisticated biological phenomenon that has long piqued the interest of researchers and healthcare experts. Carcinogenesis is fundamentally the process by which healthy cells become cancerous, causing unchecked development and progression of malignant tumors throughout the body .
Cancer is not just one illness; rather, it is a wide range of illnesses, each with distinct traits and underlying causes. Numerous genetic, environmental, and behavioral factors play a variety of roles in the dynamic and multi-step process of carcinogenesis. It entails a series of genetic and epigenetic changes that provide cells an advantage in terms of proliferation and enable them to elude the body's natural regulatory systems .
A complicated and diverse condition, cancer is brought on by a confluence of hereditary, environmental, and lifestyle factors. It is essential to comprehend the molecular pathways underlying cancer growth in order to create effective preventative and treatment plans. Recent studies have focused on the chemical substance azoxymethane to examine the role of the gastrin gene in the carcinogenic process using mice as the study species. Azoxymethane, a recognized carcinogen, has been used frequently in cancer research to cause mouse colon cancers, making it an important tool for learning about carcinogenesis .
A peptide hormone called gastrin is created by specific cells in the pancreas and the stomach. Its main job is to trigger the production of stomach acid, which helps in digestion. Recent research has nevertheless shown a further, unexpected function for gastrin in the setting of carcinogenesis .
Several theories have developed, but the exact processes underlying gastrin's protective function are currently being researched. Gastrin may have an impact on DNA repair, cell proliferation, and apoptosis (programmed cell death), all of which are necessary for limiting the growth of cancer. As part of its role in tumor suppression, gastrin may also have an impact on the immune system and the milieu surrounding tumors .
It has been demonstrated that inactivating the gastrin gene in mice causes a markedly worsened response to the carcinogen azoxymethane, increasing the incidence and development of colon tumors. This ground-breaking research confirms the significance of gastrin for colon health and raises the possibility of new directions in the fight against cancer.
- Goodman B, Gardner H. The microbiome and cancer. J Pathol. 2018;244(5):667-76.
- Me?e?-Mucha G, ?awnicka H, Mucha S. The combine effects of proglumide and fluorouracil on the growth of murine Colon 38 cancer cells in vitro. Endokrynol Pol. 2005;56(6):933-8.
- Janssen P, Rotondo A, Mulé F, et al. A comparison of glucagon?like peptides 1 and 2. Aliment Pharmacol Ther. 2013;37(1):18-36.
- Seiler N, Raul F. Polyamines and the intestinal tract. Crit Rev Clin Lab Sci. 2007;44(4):365-411.
- Gao L, Yu Q, Zhang H, et al. A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice. Sci Transl Med. 2021;13(603):eabb5071.