Journal of Pain Management and Therapy

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Case Report - Journal of Pain Management and Therapy (2022) Volume 6, Issue 1

Hydrocortisone causes transient hypertrophic cardiomyopathy and hypertension: In preterm labour

Himakshi Patil1*, Mayuri Yelekar1, Ashish Bhagat2

1Florence Nightingale Training College of Nursing, Wardha, India, Datta Meghe Institute of Medical Science (DU), Sawangi (M) Wardha

2Research Scientist, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra, India

Corresponding Author:
Himakshi Patil
Florence Nightingale Training
College of Nursing, Wardha Datta Meghe Institute of Medical Science
Sawangi (M) Wardha Maharashtra, India
[email protected]

Received: 26-Dec-2021, Manuscript No. AAPMT-22- 52057; Editor assigned: 28-Dec-2021, PreQC No. AAPMT-22- 52057 (PQ); Reviewed: 11-Jan-2022, QC No AAPMT-22-52057; Revised: 17-Jan-2022, Manuscript No. AAPMT-22- 52057 (R); Editor assigned: 24-Jan-2022, DOI:10.35841/aapmt- 6.1.101

Citation: Patil H, Yelekar M, Bhagat A. Hydrocortisone causes transient hypertrophic cardiomyopathy and hypertension: In preterm labour. J Pain Manage Ther. 2022;6(1):101.

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Entropic cardiomyopathy (HCM) is a heart muscle illness that is diverse and frequently runs in families. Cardiomyopathy that is hypertrophic is often inherited or develops as a result of a number of neuromuscular problems. HCM in neonates, particularly those born prematurely, could be a side effect of corticosteroid therapy. Cardiomyopathy is to rest of your body heart failure can result from cardiomyopathy Dilate hypertrophic and restricted cardiomyopathy are the three primaries from of cardiomyopathy The type of cardiopathy you have and how serious it is determining your treatment options, which may include drug, surgically implanted devices, heart surgery, heart surgery, or in serious situation, heart transplant Cardiomyopathy is a term used to describe diseases that affect the heart muscle. Cardiomyopathy is a condition in which your heart is failure to adequately blood pump to the rest of rest of your body. As a result, feel tired, short of breath, or have heart palpitations. Cardiomyopathy worsens with time. Treatment can help you live a better life by slowing the progression of your disease.


Hypertrophic cardiomyopathy, Neonatal, Heart, Septic shock.


In newborns with greater Aid with inotropic in septic shock and extreme pulmonary edema illness, hydrocortisone (HC) is commonly given. 1st In The term "catecholamine resistant shock" is included in the most recent Surviving Sepsis Guidelines, and corticosteroids are prescribed at this time. The issue of the appropriate target population, on the other hand, remains unanswered. There has been an increase in the number of shocks in certain subgroups. [1,2]


A number of factors, including genetic, metabolic, and endocrine, may cause neonatal HCM. PDA is common in premature babies, and it can cause cardiac remodeling and defects similar to those seen in adults. HCM, greetings. Early heart disease and ischemic heart disease, functional and structural cardiac remodeling, systemic vascular effect, increase hypertension, high risk mother, pulmonary cardiac disease, mechanism and therapeutic approaches, intrauterine infection., intracerebral hemorrhage, ischemic shook, ischemic brain injury, acquired brain injury. [3,4]

Sing and system: Chest pain, especially after exercising, Shortness of breath, particularly when exercising, Fatigue is a common symptom, The sensation of being lightheaded, Ankles, feet, legs, abdomen, and nek veins all swell.

Patient information

Children admitted in AVBRH, in May 2021 orthopnea, and paroxysmal nocturnal dyspnea are all sings of hypertrophic. Dyspnea, syncope, and presyncope, angina, cardiomyopathy (HCM) cardiac death.

Family history

Hydrocortisone in a preterm child, and there were four members in the family. Except for my patient, who was admitted to the hospital, none of the other members of the group were sick My patient had a benign transient hypertrophic cardiomyopathy and hypertension related with

Past History: The patient has no any major history.

Clinical finding

Large head, low body temperature, breathing respiratory distress, lack of reflex and cardiac death are all symptoms of hypertrophic cardiomyopathy (HCM). Asymmetric septal hypertrophy, also known as hypertrophic cardiopathy is a disorder in which heart muscle cell expand, thickening the wall of the lower heart chambers (usually the left ventricle).

Physical examination

Hypertrophic cardiomyopathy is usually diagnosed with an echocardiography. Ultrasound waves are used in this test to detect if the muscle in your heart is excessively thick. It also indicates how properly the chambers and valves of your heart are pumping blood.

Diagnostic evaluation

Electrocardiogram (ECG or EKG), chest Xray, MRI, CT scan, total blood count, kidney function test, liver function test.

Therapeutic investigation

Metoprolol (Toprol-XL), propanol (Inderal, InnoTrans XL), and atenolol (Adeniran XL) are beta blockers (Tenormin) Verapamil (Verlan, Callan SR) and diltiazem are calcium channel blockers (Cardizem, Tiazac) Disopyramide (Pacerone) and amiodarone (Pacerone) are heart rhythm medicines (Norpace) The first line of treatment for severe symptomatic hyponatremia is an intravenous infusion of hypertonic fluid. beta s such as metoprolol ( lopressol , toprol- XL) propanol ( inderal, Innopran XL), and atenolol (Inderal, Innopran XL) may be used to treat hypertrophic cardiomyopathy and accompanying symptoms (Tenormin) Verapamil (Verelan, Calan SR) and diltiazem are calcium channel blockers (Cardizem, Tiazac)Small vascular illness, myocyte and myofibrillar disorganization, and fibrosis with or without myocardial hypertrophy are all symptoms of hypertrophic cardiomyopathy (HCM), a hereditary heart muscle ailment that damages sarcomeric proteins. These characteristics can cause serious heart symptoms and can be a source of arrhythmias. Prior to the discovery of disease-causing genes, the World Health Organization (WHO).

Within 4 weeks, there was no left ventricular outflow tract blockage or arrhythmias, indicating a reversible courser.


This study shows that HC therapy is linked to hypertrophic cardiomyopathy (HCM) in premature babies. HCM is thought to be the most frequent of the hereditary cardiovascular illnesses, caused by a variety of abnormalities in genes that code for heart sarcomere proteins. There are eleven mutant genes, the majority of which code for beta-myosin heavy chain [4-6] recently linked to HCM, accounting for nearly half of all patients. Non- sarcomeric Protein mutations can cause storage disease including Fabry disease, pompe disease, Friedrich ataxia, mitochondrial disorders, and drugs like tacrolimus, which need molecular diagnostics. Several epidemiological studies have found a link between [7,8].

These case, the fetal echocardiography normal, the patient did not have any clinical findings cardiomyopathy [9].Abnormal modulation of peripheral resistance, without cardiac function is not good, common of hypertension under like shock in the immediate postnatal period, especially in preterm newborns. The realize of proinflammatory cascades that leads to vasodilation is also linked to sepsis-induced shock. In exceptionally severe cases [10]. The resulting application of lagged TE on neonatal cardiorespiratory data showed two distinct interaction profiles of directionality a fast and quickly decaying information transfer from RESP to Convergent findings with regard to the directionality from RESP to RR were obtained by Faes et al. (2014), showing that the fast information flow from breathing to HR is associated with the respiratory sinus arrhythmia. Furthermore, the timing of activation of the information flow profile is comparable to the known latencies of activation for the sympathetic and parasympathetic arms of the nervous system. The sympathetic branch intervenes on a slower time scale but its effect on the target system lasts longer whereas the parasympathetic has a punctate, yet rapidly action. Thus, the reported lagged TE dynamics might reflect that information transfer directionalities are driven by different autonomy. RR, and a slower but more stable transfer from RR to RESP [11].

This is relevant in the context of possible approaches for quantification of sympathetic activation. A state of sympathetic hyperactivity has been in fact reported as associated with an increase in cardiovascular morbidity and mortality (Brook and Julius, 2000; Nakamura et al., 2016). Thus, while several heart rate variability parameters can assess parasympathetic activity [12]. Renature babies with hypotension resistant to volume expansion and vasopressor can be treated in a variety of ways. HC inhibits catecholamine metabolism and suppress the inflammatory response. It also induced the cardio vascular adrenergic receptor; there is a swift response to HC administration [13]. Increased intracellular calcium supply, resulting in a 2 hour increase in response to adrenergic agents. Hypertension, hyperglycemia, GI hemorrhage, and perforation are the most common short term side effects of HC. Cause of cardiomyopathy is myocardial thickenings is unknown. Hypertrophic cardiomyopathy cause left ventricular hypertrophy by acting on cardiac myocytes 10 and 11 Despite the fact that the ventricle size is frequently normal [14].

Because of the thickening, resulting in Obstructive hypertrophy cardiomyopathy echocardiography is the most common method for detecting HC M?the ventricle and the damaged heart muscle shift as well, disrupting electrical signal in the heart and causing arrhythmias. Extreme physical exertion that causes arrhythmias can result in cardiac arrest in some case, resulting in obstructive hypertrophic cardiomyopathy [15].

To reduce myocardial oxygen demand, channel blockers are used and hence increase compliance by slowing the heart rate. Septal myectomy or ablation, as well as an implanted cardioverter-defibrillator, are further options. HCM caused by HC is usually a harmless condition. Illness that resolves within a few weeks of withdrawal; also, none of the cases in the literature show hypertension. Finally, advise that the risk of benefits ratio should be carefully, when corticosteroid given in neonatal septic, particularly in preterm infants. In some situations, HCM is linked to lactiferous arrythmias, thus an adequate monitor, such as an echocardiogram and an electrocardiogram, should be performed to help guide cardiovascular care. It is suggested that preventive approaches be used to monitor the harmful effects of the drug. Cardiomyopathy is condition of heart muscle thickness abnormality, many people hyperopic cardiomyopathy undergoes of many systems live Regular severe complication dyspnea chest pain, electrical systems can occur small corporation person cardiomyopathy. HCM patients may experience a variety of symptoms. People may have a variety of symptoms, including weariness, limb edema, and shortness of breath. It can also cause chest pain or make you pass out. When a person is dehydrated, the symptoms may be exacerbated. Heart failure, an irregular heartbeat, and sudden cardiac death are all possible complications.


In a preterm baby, hydrocortisone caused transient hypertrophic cardiomyopathy and hypertension. A case study.


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