Archives of General Internal Medicine

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Commentary - Archives of General Internal Medicine (2021) Volume 5, Issue 10

How does corticosteroid medication affect immune system?

Ali Esmael*

Department of Vascular Surgery, Mansoura Health Insurance Hospital, Mansoura, Egypt

Corresponding Author:
Dr. Ali Esmael
Department of Vascular Surgery
Mansoura Health Insurance Hospital
E-mail: [email protected]

Accepted date: 16 November, 2021

Citation: Esmael A. How does corticosteroid medication affect immune syatem? Arch Gen Intern Med. 2021;5(10):8.

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Corticosteroids square measure secretion mediators created by the cortex of adrenal glands that additionally categorize into glucocorticoids, mineralocorticoids, and steroid sex hormones. They're employed in an excessiveness of conditions, ordinarily known as steroid-responsive disorders and dermatoses. Corticosteroids represent an ambiguous weapon system-vital profit with a coffee incidence of adverse effects may be expected if employed incorrect dose and for a restricted duration; but, wrong dose or length and unmindful withdrawal in prolonged administration will have harmful effects.


Corticosteroids, Glucocorticoids, Immune System, Mineralocorticoids, Steroid sex hormones.


Corticosteroids square measure used across all medical specialties. This activity reviews the must-know properties of this cluster of medicine, their broad indications and contraindications, ways that of administration, adverse event profile, sensible aspects of the pharmacological medicine of various molecules, observance necessities, approach to maximize the profit and minimize adverse effects, and clinically relevant drug-interactions pertinent for all specialists whether or not employed in isolation or administered by an interprofessional team. Sometimes the system does not work properly, and folks develop inflammatory conditions that cause injury rather than protection. Corticosteroids decrease inflammation and stop this injury. They conjointly have an effect on however white blood cells work and scale back the activity of the system. Hydrocortisone injections square measure accustomed treat swollen or painful joints, like once the associate injury or if you have got the disease. The corticoid is injected directly into the painful joint. This can be referred to as AN intra-articular injection. The joints most frequently injected are the shoulder, elbow, knee, hand, wrist joint, or hip. Corticoid injections also won’t treat painful tendons and redness when a tiny low bag of fluid that cushions a joint gets inflamed. They generally won’t treat muscle pain once it's during an explicit space. The injections typically facilitate relieve pain and swelling and build movement easier. The advantages will last for many months. Corticoid could be a form of drug called steroid or corticosteroid. Corticosteroids suppress the immune system, which has a substantial influence on the body. Doctors use corticosteroids after other treatments have failed. Corticosteroids can cause blood sugar levels to rise, which is dangerous for diabetics. Corticosteroids may be hazardous to those who have one or more of the following conditions: Obesity, depression, sores caused by glaucoma or cataracts, heart failure or just a recent heart attack, liver issues due to high blood pressure, ongoing infections epilepsy, wounds that are rather huge.


Corticosteroids aren't equivalent to anabolic steroids. Corticoid injections are solely obtainable on prescription. They are typically given by a specially trained doctor during a GP's surgery or hospital clinic. In an emergency, medical workers might offer higher dose corticoid injections to treat severe respiratory illness, sensitivity, severe shock because of injury or infection, or failure of the adrenal glands. Oral and injectable general corticosteroids are steroid hormones prescribed to decrease inflammation in diseases and conditions like inflammatory disease (rheumatoid inflammatory disease, for example), inflammatory bowel disease, regional enteritis, asthma, bronchitis, some skin rashes, and allergic or inflammatory conditions that involve the nose and eyes. Samples of general corticosteroids embrace Cortef, cortisone, Deltasone (Prednisone Intensol), glucocorticoid (Orapred, Prelone), and methylprednisolone (Medrol, Depo-Medrol, Solu-Medrol). Some of the effects of general corticosteroids are swelling of the legs, high blood pressure, headache, simple bruising, facial hair growth, diabetes, cataracts, and swelling of the face.

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