Journal of Clinical Endocrinology Research

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Image Article - Journal of Clinical Endocrinology Research (2022) Volume 5, Issue 5

Heart rate variability and stress index after taking 1 tab. Validol followed by consumption of 1 cup of instant coffee in an adult male

Ivan Domuschiev*

Department of Internal Diseases, Plovdiv City, Bulgaria

*Corresponding Author:
Ivan Domuschiev
Department of Internal Diseases
Plovdiv City, Bulgaria
E-mail: [email protected]

Received: 30-Sep-2022, Manuscript No. AAJCER-22-79258; Editor assigned: 03-Oct-2022, PreQC No. AAJCER-22-79258(PQ); Reviewed: 17-Oct-2022, QC No. AAJCER-22-79258; Revised: 19-Oct-2022, Manuscript No. AAJCER-22-79258(R); Published: 25-Oct-2022, DOI:10.35841/aajcer-5.5.121

Citation: Domuschiev I. Heart rate variability and stress index after taking 1 tab. Validol followed by consumption of 1 cup of instant coffee in an adult male. J Clin Endocrinol Res. 2022;5(5):121

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Introduction

Validol (Menthyl valerate) is a menthyl ester of isovaleric acid. It has long been widely used as a sedative for increased nervous tension and stress with a good effect [1,2,3]. The maximum relaxing effect of Validol occurs 10 minutes after its sublingual intake [2]. Coffee is the most commonly used drink in the world to increase tone and invigorate [4,5,6]. The maximum tonic effect of caffeine occurs 45 minutes after its consumption [7]. The study of heart rate variability parameters is the most accurate method for quantitative analysis of the sympatho-vagal balance of the autonomic nervous system [4,7].

Methodology

• The subject is a 61-year-old man. He weighs 75 kg and is 178 cm tall (BMI=24).

• To record the heart activity, we used the "Kalenji" Chest Strap (with BLE Bluetooth transmission of heart signals). We analyzed the obtained data with the "Kubios HRV" software.

• We performed 3 times short term (3 min.) heart rate variability measurements.

• The first HRV measurement was performed in the morning at 8 h after awakening from sleep under basal conditions.

• The second HRV measurement was made 10 minutes after sublingual intake of 1 tablet. (0.06 gr.) Validol (Menthyl valerate).

• The third HRV - measurement is realized 45 minutes after the consumption of 1 cup of instant coffee.

• All these 3 HRV - measurements were done in a lying position in complete rest and silence.

Results

The obtained results are presented in Figure. 1, 2, 3, 1A, 2A, 3A, 1B, 2B and 3B.

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Figure 1: In the morning after waking up before Validol.

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Figure 1A: 10 minutes after taking 1 tablet Validol.

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Figure 1B: 45 minutes after consuming 1 cup of instant coffee.

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Figure 2: (In the morning after waking up before Validol).

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Figure 2A: 10 minutes after taking 1tablet Validol).after waking up before Validol).

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Figure 2B: 45 minutes after consuming 1 cup of instant coffee.

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Figure 3: In the morning after waking up before Validol.

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Figure 3A: 10 minutes after taking 1 tablet Validol.

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Figure 3B: 45 minutes after consuming 1cup of instant coffee.

Conclusion

The quality sleep is the best relaxant for the body (best heart rate variability and lowest stress index - better result compared to Validol). Coffee increases the sympathetic activity, as a result of which the stress index increases.

References

  1. Bondarenko IP, Liashenko MM, Chirkov SN, et al. A comparative evaluation of the antianginal action of commercially and noncommercially produced validol in neurocirculatory dystonia and stenocardia. Lik Sprava. 1996;3(4):110-3.
  2. Indexed at, Google Scholar

  3. Tsvetkova B, Pencheva I, Zlatkov A, et al. Validated gc method for determination of validol in tablet dosage forms. Asian J Pharm Clin Res. 2012;5(3):96-7.
  4. Google Scholar

  5. Food and Chemical Toxicology.1982;20:735.
  6. Sondermeijer HP, Van marle AG, Kamen P, et al. Acute effects of caffeine on heart rate variability. Am J Card. 2002;90(8):906-7.
  7. Indexed at, Google Scholar, Cross Ref

  8. Corti R, Binggeli C, Sudano I, et al. Coffee leads to activation of the sympathetic nervous system. Eur Heart J. 2000;21(105):24-28.
  9. Indexed at, Google Scholar, Cross Ref

  10. Corti R, Binggeli C, Sudano I, et al. Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: role of habitual versus nonhabitual drinking. Circulation. 2002;106(23):2935-40.
  11. Indexed at, Google Scholar, Cross Ref

  12. De Oliveira RA, Araújo LF, De Figueiredo RC, et al. Coffee consumption and heart rate variability: the Brazilian longitudinal study of adult health (ELSA-Brasil) cohort study. Nutrients. 2017;9(7):741.
  13. Indexed at, Google Scholar, Cross Ref

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