Journal of Clinical Endocrinology Research

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Mini Review - Journal of Clinical Endocrinology Research (2022) Volume 5, Issue 5

Extending neuroendocrinology: strain, sexuality, and physiological and behavioural control

Benjamin parker desouza*

Department of Psychology, University of Connecticut, Storrs, USA

*Corresponding Author:
Benjamin parker desouza
Department of Psychology
University of Connecticut
Storrs, USA

Received: 03-Oct-2022, Manuscript No. AAJCER-22-80518; Editor assigned: 05-Oct-2022, PreQC No. AAJCER-22-80518 (PQ); Reviewed: 19-Oct-2022, QC No. AAJCER-22-80518; Revised: 21-Oct-2022, Manuscript No. AAJCER-22-80518 (R); Published: 27-Oct-2022, DOI:10.35841/aajcer-5.5.123

Citation: Desouza BP. Extending neuroendocrinology: Strain, sexuality, and physiological and behavioural control. J Clin Endocrinol Res. 2022;5(5):123

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The definition of "neuroendocrinology" has been expanded to include the reciprocal communication between the brain and body via hormonal and neural pathways as a result of the identification of steroid hormone receptors in brain areas that mediate every aspect of brain function. Because it perceives and judges what is hazardous and determines the behavioural and physiological reactions to the stressor, the brain is the primary organ of stress and adaptation to stress. In response to stress, the adult and developing brain exhibits remarkable structural and functional plasticity, including synapse turnover, dendritic remodelling, and neuronal replacement. Stress leads to an imbalance in the neural circuitry that supports cognition, judgment, anxiety, and mood, which can change how these behaviours and behavioural states are expressed. Furthermore, negative early experiences interact with specific gene alleles to produce long-lasting effects on the body and brain over the course of a lifetime via epigenetic mechanisms. Although prevention is crucial, there is hope for therapies that consider how the brain and body interact thanks to the brain's plasticity.


Sex, Neuroendocrine, Anxiety, Mood, Brain's plasticity.


Geoffrey Harris' essential finding of the hypothalamus and pituitary's connection laid the groundwork for comprehending brain-body communication through the neuroendocrine system. The study of neuroendocrinology has developed as initially envisioned and supported by the hypothalamic hormone-releasing factors. At the same time, it was discovered that steroid hormones may attach to intracellular receptors that control gene expression in organs like the liver or, in the case of sex hormones, the prostate and uterus. The pituitary and the hypothalamus were the primary targets of steroid hormone feedback to control neuroendocrine activity, and this significant research continues to reveal crucial elements of neuroendocrine regulation. The field of neuroendocrinology investigates the neuroendocrine, autonomic, immune, and metabolic systems as well as two-way brain-body communication. According to the findings of this study, hormones and other cellular mediators cooperate to remodel the structure of the brain. The effects of adverse early-life experiences and the relationship between socioeconomic status and health through the development of the concept of allostatic load are just two examples of the actions that take place via epigenetic mechanisms involving both genomic and non-genomic processes over the course of a person's life. These findings in animal models are also being continuously translated to the human condition.

Outside of the hypothalamus, receptors

We found receptors for adrenal steroids in the rat and later the rhesus monkey's hippocampus formation by giving 3H corticosterone to rats with adrenalectomies [1]. Such receptors were discovered in the hippocampal equivalent in other species, including birds, by other research. These discoveries expanded the idea that glucocorticoids controlled the HPA axis through negative feedback to include effects of adrenal steroids on other mental processes including memory, learning, mood regulation, and other behavioural elements [2].

Output to several interconnected mediators and allostatic load

Originally, the term "neuroendocrinology" referred to the control of neuroendocrine function by the hypothalamus and pituitary. Focused upon the return loop of feedback of steroid hormones on the brain to affect molecular, cellular, physiological and behavioural processes throughout the entire brain [3]. This feedback now includes action in the brain of metabolic hormones such as insulin, ghrelin, insulin-like growth factor 1 (IGF1) and leptin specific uptake systems and acting upon receptors residing in hippocampus and other brain regions [4].

Disparities in sex

The impact of stress and sex hormones on the hippocampus and prefrontal cortex varies significantly depending on the gender, expanding the ground-breaking study of Harris & Levine. Dendrites in CA3 neurons and medial prefrontal cortex neurons do not decrease under prolonged stress in females. Neurons that project cortically in the medial prefrontal cortex shrink under chronic stress in males but not in females, whereas neurons that project to the amygdala extend under chronic stress in females but not in males. There must be oestrogen in the bloodstream for the females to react in this manner [5].


The initial definition of "neuroendocrinology" based on the work of geoffrey harris has been enlarged to incorporate many elements of reciprocal brain-body communication. Circulating hormone activities throughout the brain on nearly every component of brain function. Along with the growing study of gene x environment interactions currently known as "epigenetics," and with the new understanding of the life-course perspective for human health and sickness.


  1. Capatina C, Wass JA. 60 years of neuroendocrinology: Acromegaly. Int J Endocrinol. 2015;226(2):141-60.
  2. Indexed at, Google Scholar, Cross Ref

  3. Spiga F, Walker JJ, Gupta R, et al. 60 years of neuroendocrinology: Glucocorticoid dynamics: Insights from mathematical, experimental and clinical studies. Int J Endocrinol. 2015;226(2):55-66.
  4. Indexed at, Google Scholar, Cross Ref

  5. McEwen BS, Gray JD, Nasca C. 60 years of neuroendocrinology: Redefining neuroendocrinology: Stress, sex and cognitive and emotional regulation. Int J Endocrinol. 2015;226(2):67-83.
  6. Indexed at, Google Scholar, Cross Ref

  7. Habib KE, Gold PW, Chrousos GP. Neuroendocrinology of stress. Clin Endocrinol Metab. 2001;30(3):695-728.
  8. Indexed at, Google Scholar, Cross Ref

  9. Grachev P, Millar RP, O'Byrne KT. The role of neurokinin B signalling in reproductive neuroendocrinology. J Neuroendocrinol. 2014; 99(1):7-17
  10. Indexed at, Google Scholar, Cross Ref

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