Journal of Molecular Oncology Research

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Perspective - Journal of Molecular Oncology Research (2023) Volume 7, Issue 4

Emerging lung functions and vaccination against pneumonia

Jun Wang*

Department of Pulmonology, Chiba University, Kamogawa, Chiba, Japan

Corresponding Author:
Jun Wang
Department of Pulmonology,
Chiba University,

Received: 21-Nov-2022, Manuscript No. AAMOR-22-81370; Editor assigned: 23-Nov-2022, AAMOR-22-81370 (PQ); Reviewed: 07-Dec-2022, QC No. AAMOR-22-81370; Revised: 27-Mar-2023, Manuscript No. AAMOR-22-81370 (R); Published: 04-Apr-2023, DOI:10.35841/aamor.7.4.176

Citation: Wang J. Emerging lung functions and vaccination against pneumonia. J Mol Oncol Res. 2023;7(4):1-2.

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An illness known as pneumonia causes inflammation of the air sacs in one or both lungs. The air sacs could become clogged with fluid or pus (purulent material), which would result in a cough with pus or phlegm, a fever, chills and breathing difficulties. Pneumonia can be caused by a wide range of microbes, including bacteria, viruses and fungus. According to medicine, it is an inflammation of the lung parenchyma that is frequently but not always brought on by infections. Bacteria, viruses, fungus and parasites are only a few of the numerous causes of pneumonia. The interprofessional team’s role in the treatment of these patients is highlighted as this activity explores the cause, pathophysiology, presentation and diagnosis of bacterial pneumonia.


Pneumonia, Inflammation, Bacterial pneumonia, Infection, Numerous


Pneumonia is a sickness that typically results from an infection that causes the lungs to swell and become inflamed, decreasing oxygen exchange and producing a cough and shortness of breath. All ages are affected, but youngsters and the elderly are most frequently affected. Pneumonia is the most frequent cause of death among children worldwide. In the past, advancements in housing, diet and air quality have decreased pneumonia related fatalities in industrialised nations. Today, access to inexpensive, efficient therapies or vaccination can also save a large number of pneumonia related fatalities in impoverished nations. But as we point out here, there are significant gaps in our knowledge of the epidemiology, aetiology and pathophysiology of pneumonia that, if closed, could hasten the disease’s control and lower the death rate among young children [1].


The organism that causes pneumonia, RSV, presents the most difficult problems for vaccine development. It can result in a wide range of disease severity in new-borns, especially those less than three months old, from coryza (runny nose) to bronchiolitis to alveolar pneumonia. RSV can be found in onefifth of children with Lower Respiratory Tract Infections (LRTIs) who are hospitalised in the Gambia. In several poor nations, the rate of severe RSV caused pneumonia among children under the age of five and an effective RSV vaccine could have a significant influence on paediatric pneumonia [2].

Sadly, unanticipated findings from preliminary research have seriously impeded the development of RSV vaccinations. In addition to failing to provide any protection against infection, a vaccination given to kids in the 1960's that contained formalin inactivated RSV increased the frequency and severity of lung illness after a subsequent spontaneous infection. In one trial, compared to 5% of the control group’s kids, nearly 80% of vaccine recipients required hospitalisation for an LRTI [3]. Additionally, immunisation after an RSV infection has been cleared up does not prevent reinfection, but it does cause a decline in illness severity and a change from lower to upper respiratory tract disease. Immunity is each humoral and mobileular mediated at distinct degrees of infection; neutralizing antibodies unique for the F and G glycoproteins shield towards infection and RSV-unique CTLs terminate an infective episode. Natural publicity to RSV stimulates a balanced CD4+ Th mobileular reaction with each proinflammatory Th1 cells (secreting IFN-γ) and antiinflammatory Th2 cells (secreting IL-10) [4]. However, one speculation explaining disorder enhancement most of the babies administered the vaccine containing formalin inactivated RSV is that the vaccine biased the immune device to provide a predominantly Th2 reaction upon later publicity to virus (135). Ideally, vaccines towards RSV disorder need to result in the equal balanced Th1/Th2 reaction of herbal immunity. They need to additionally cowl the antigenically awesome corporations RSV A and RSV B [5].


Pneumonia is an international ailment this is generally curable in advanced nations however regularly deadly in growing nations. The international notion of pneumonia as a public fitness trouble is emasculated via way of means of its acquainted and benign photograph with inside the industrialized world. Pneumonia has no UN organization to spotlight its significance and no fund or collection of world networks to recommend for drugs, vaccines or care. The ambiguity of its diverse acronyms (e.g. ARI and LRTI) similarly undermines its notion as a single, tractable trouble.

The energetic reaction to SARS and the tremendous assist for pandemic influenza preparedness (~$10 billion) via way of means of the worldwide public fitness network reveal what may be accomplished whilst the sector perceives an enormous fitness risk. Pneumonia, with an international burden of 5,000 early life deaths each day, is a continuous, tangible risk that has to cause comparable responses movement and studies on pneumonia are urgently required.


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