Journal of Food Nutrition and Health

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (202) 780-3397

Commentary - Journal of Food Nutrition and Health (2023) Volume 6, Issue 5

Dietary walnut supplementation protects mice from dss-induced intestinal injury

Gideon Obasanmi *


*Corresponding Author:
Song Wang
Department of Nutritional Sciences
Oklahoma State University
Stillwater, USA.

Received:25-Sep-2023, Manuscript No. AAJFNH-23-114682; Editor assigned: 27-Sep-2023,PreQC No. AAJFNH-23-114682 (PQ); Reviewed:12-Oct-2023,QC No. AARRI-23-114682; Revised:17-Oct-2023, Manuscript No. AAJFNH-23-114682(R); Published:24-Oct-2023,DOI:10.35841/aarrgs-6.5.171

Citation: Gao F. Dietary walnut supplementation protects mice from dss-induced intestinal injury. J Food Nutr Health. 2023; 6(5):172

Visit for more related articles at Journal of Food Nutrition and Health


In recent years, there has been growing interest in the potential health benefits of including various nuts in our diets. Among these, walnuts stand out not only for their delicious taste but also for their remarkable nutritional profile. Walnuts are rich in essential fatty acids, antioxidants, and various bioactive compounds, making them a subject of extensive research. One such study of particular significance is the investigation into how dietary walnut supplementation can protect mice from dextran sulfate sodium (DSS)-induced intestinal injury. This research sheds light on the potential therapeutic applications of walnuts in managing gastrointestinal disorders. Dextran sulfate sodium, commonly referred to as DSS, is a chemical compound used in laboratory studies to induce intestinal injury and inflammation in rodents. DSS induces a range of symptoms in mice that closely resemble human inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis. These diseases are characterized by chronic inflammation of the gastrointestinal tract, leading to symptoms like abdominal pain, diarrhea, and weight loss. [1].

The study in question aimed to investigate whether dietary walnut supplementation could mitigate the severity of DSS-induced intestinal injury, thus potentially offering a natural dietary approach to managing IBD and related conditions. Walnuts have long been recognized as a nutritionally dense food source. They are an excellent source of alpha-linolenic acid (ALA), a type of omega-3 fatty acid. Omega-3 fatty acids are known for their anti-inflammatory properties, which can be particularly beneficial in conditions marked by chronic inflammation, such as IBD. Moreover, walnuts are packed with antioxidants, including vitamin E and polyphenols, which help combat oxidative stress and inflammation in the body. These antioxidants play a crucial role in protecting the gut lining from damage and maintaining its integrity [2].

To investigate the potential protective effects of walnuts against DSS-induced intestinal injury, researchers conducted a controlled animal study. Mice were divided into two groups: one group was fed a standard diet, while the other received a diet supplemented with walnuts. After a specified period, both groups were exposed to DSS to induce intestinal injury. The results were striking. Mice that had been fed a walnut-enriched diet exhibited significantly less severe intestinal injury compared to those on the standard diet. This was evident through various markers, including reduced inflammation, improved intestinal barrier function, and a decrease in disease-related symptoms [3].

Several mechanisms underlie the protective effects of walnut supplementation against DSS-induced intestinal injury: Anti-Inflammatory Properties: Walnuts' high content of omega-3 fatty acids helps reduce the production of inflammatory molecules in the gut, thereby lowering inflammation levels and mitigating the damage caused by DSS. Gut Barrier Function: Walnuts' antioxidant compounds, such as polyphenols and vitamin E, have been shown to strengthen the integrity of the gut barrier. This fortification helps prevent harmful substances from crossing the intestinal lining and entering the bloodstream. Modulation of Gut Microbiota: Emerging research suggests that walnuts may positively influence the composition of the gut microbiota. A balanced and diverse gut microbiome is crucial for overall gut health and immune function. Nutrient Density: Walnuts are rich in essential nutrients, including fiber, vitamins, and minerals. These nutrients provide essential support to the body, aiding in the repair and maintenance of the gut lining. Implications for Human Health The findings of this study have significant implications for human health. While this research focused on mice, the similarities between mouse and human gut physiology make the results highly relevant for understanding potential therapeutic options for individuals with IBD or other gastrointestinal disorders [4].

Incorporating walnuts into the diet, either as a snack or as an ingredient in various dishes, could be a simple and tasty way to support gut health. However, it is essential to consult with a healthcare professional or nutritionist before making significant dietary changes, especially if you have a pre-existing medical condition or are taking medications. While the results of this study are promising, further research is needed to fully understand the potential of walnut supplementation in human gastrointestinal health. Some important considerations for future research include: Clinical Trials: Conducting human clinical trials to validate the protective effects of walnuts on intestinal health and identify optimal dosages for therapeutic purposes. Nutritional Diversity: Evaluating the synergistic effects of including walnuts alongside other gut-friendly foods in the diet to enhance overall gut health. Long-term Effects: Investigating the long-term impact of walnut supplementation on gastrointestinal health, as chronic conditions often require sustained interventions [5].


The study highlighting the protective effects of dietary walnut supplementation against DSS-induced intestinal injury in mice offers promising insights into the potential of walnuts as a natural dietary approach for managing gastrointestinal disorders. Walnuts' rich content of anti-inflammatory omega-3 fatty acids, antioxidants, and essential nutrients makes them a compelling candidate for supporting gut health. While further research is needed to fully understand the scope of these benefits in humans, incorporating walnuts into a balanced diet may be a simple and enjoyable way to promote intestinal well-being. As the science continues to evolve, walnuts could become a valuable component of a holistic approach to managing inflammatory bowel diseases and related conditions, ultimately improving the quality of life for those affected by these challenging disorders.



  1. Savoini G. Effects of fat supplementation in dairy goats on lipid metabolism and health status. Animals (Basel). 2019;9, 917. 
  2. Indexed at, Google scholar, Cross Ref

  3. Waldron MK, Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish? and linseed?oil containing diets at the same n?6:n?3 fatty acid ratio. Lipids, 2012; 47:425–34.
  4. Indexed at, Google scholar, Cross Ref

  5. Gomez Ruiz JA. Statement on the human dietary exposure assessment to newly expressed proteins in GM foods. EFSA Journal2019;17:5802.
  6. Indexed at, Google scholar, Cross Ref

  7. Koch MS. The food and environmental safety of Bt crops. Frontiers in Plant Science. 2015; 6:283. 
  8. Indexed at, Google scholar, Cross Ref

  9. Le Corre V, Adaptive introgression from maize has facilitated the establishment of teosinte as a noxious weed in Europe. Proc Nati Acad of Scien USA. 2020; 117:25618–627.
  10. Indexed at, Google scholar, Cross Ref

Get the App