Journal of Molecular Oncology Research

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Perspective - Journal of Molecular Oncology Research (2023) Volume 7, Issue 4

Colorectal cancer-related multiple cavitary lung lesions responding to chemotherapy.

Alin-Young Kim *

Department of Oncology, University of Ulsan, Songpa-gu, Korea

*Corresponding Author:
Alin-Young Kim
Department of Oncology
University of Ulsan
Songpa-gu, Korea

Received:26-Jun-2023, Manuscript No. AAMOR-23-103553; Editor assigned:28-Jun-2023, PreQC No. AAMOR-23-103553 (PQ); Reviewed:11-July-2023, QC No. AAMOR-23-103553; Revised:15July-2023, Manuscript No. AAMOR-23-103553 (R); Published:21-July-2023, DOI:10.35841/ aamor-7.4.184

Citation: Kim AY. Colorectal cancer-related multiple cavitary lung lesions responding to chemotherapy. J Mol Oncol Res. 2023;7(4):184

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Colorectal cancer is a type of cancer that originates in the colon or rectum, which are parts of the digestive system. Chemotherapy is an essential treatment modality used in the management of colorectal cancer. It involves the use of anti-cancer drugs to destroy cancer cells or inhibit their growth. Multiple cavitary lung lesions in the context of colorectal cancer are a relatively uncommon phenomenon. The development of cavitary lesions is thought to result from tumor necrosis and subsequent liquefaction. While the exact mechanisms underlying the formation of these lesions remain unclear, several factors, including central tumor necrosis, infection, and ischemia, have been proposed [1].

Colorectal cancer is a malignant disease that primarily affects the colon or rectum, but it can also spread to other organs, including the lungs. Lung metastases from colorectal cancer typically appear as solid nodules on imaging studies. However, in some rare cases, colorectal cancer can manifest as multiple cavitary lung lesions. These lesions present a unique diagnostic and therapeutic challenge due to their distinctive characteristics and potential complications. Chemotherapy drugs used in the treatment of colorectal cancer, such as Fluorouracil (5-FU), Capecitabine, Oxaliplatin, and Irinotecan, have demonstrated efficacy in reducing tumor burden and prolonging survival. While the effectiveness of chemotherapy in solid lung metastases has been well-established, its role in the management of cavitary lung lesions is relatively less explored [2].

The diagnosis of colorectal cancer-related multiple cavitary lung lesions requires a comprehensive evaluation, including clinical history, radiological imaging, and histopathological analysis. The identification of primary colorectal cancer, along with the presence of compatible lung lesions, aids in establishing the diagnosis. Additional investigations, such as bronchoscopy, may be necessary to rule out other causes of cavitary lung lesions, such as infectious etiologies. While chemotherapy can be effective in treating colorectal cancer, it may also be associated with certain side effects. These side effects can include nausea, vomiting, fatigue, hair loss, diarrhea, neuropathy, and decreased blood cell counts. Supportive care measures are often employed to manage these side effects and improve patient comfort during treatment. The management of colorectal cancer-related multiple cavitary lung lesions typically involves a multimodal approach. Chemotherapy plays a crucial role in the treatment of both the primary colorectal cancer and the metastatic lung lesions. The selection of chemotherapy agents is based on the specific characteristics of the colorectal cancer, including the presence of certain genetic mutations or biomarkers that can guide targeted therapies. Systemic chemotherapy aims to control tumor growth, improve patient outcomes, and potentially shrink or stabilize the cavitary lung lesions [3].

While the response of multiple cavitary lung lesions to chemotherapy may vary, studies have reported favorable outcomes in select cases. The reduction in tumor burden and subsequent resolution of cavitary lesions have been observed in some patients, leading to improved symptoms and prolonged survival. However, it is important to note that the response to chemotherapy may differ among individuals, and the treatment approach should be tailored to each patient's unique clinical situation. Analyze cases of colorectal cancer-related multiple cavitary lung lesions that have responded to chemotherapy. By examining the existing literature and presenting relevant clinical cases, we seek to elucidate the efficacy of chemotherapy in achieving tumor regression, improving symptoms, and potentially increasing survival in patients with this distinctive presentation [4].

Colorectal cancer-related multiple cavitary lung lesions represent a rare and intriguing manifestation of metastatic disease. While the management of such lesions poses unique challenges, emerging evidence suggests that chemotherapy can play a significant role in achieving favorable outcomes for these patients. Although colorectal cancer-related multiple cavitary lung lesions are rare, the existing evidence suggests that chemotherapy can be an effective treatment modality. These findings highlight the importance of considering individualized treatment approaches for patients with this distinct clinical presentation [5].


  1. Moertel CG. Chemotherapy for colorectal cancer. N Engl J Med. 1994;330(16):1136-42.
  2. Google Scholar
  3. Helgason HH, Engwegen JY, Zapatka M, et al. Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry. Oncol Rep. 2010;24(1):57-64.
  4. Indexed at, Google Scholar, Cross Ref

  5. Gill S, Thomas RR, Goldberg R. Colorectal cancer chemotherapy. Aliment Pharmacol Ther. 2003;18(7):683-92.
  6. Google Scholar


  7. Tirumani SH, Kim KW, Nishino M, et al. Update on the role of imaging in management of metastatic colorectal cancer. Radiographics. 2014;34(7):1908-28.
  8. Indexed at, Google Scholar, Cross Ref

  9. Ragnhammar P, Hafstrom L, Nygren P, et al. A systematic overview of chemotherapy effects in colorectal cancer.. Acta Oncol. 2001;40(2-3):282-308.
  10. Indexed at, Google Scholar, Cross Ref

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