Rapid Communication - Journal of Clinical Oncology and Cancer Research (2022) Volume 5, Issue 6
An study of current chemotherapeutic methods for treating humans
Department of Biology, University of Massachusetts, Boston, MA, USA
- *Corresponding Author:
- William Kane
Department of Biology
University of Massachusetts
Boston, MA, USA
Received: 01-Dec-2022, Manuscript No. AACOCR-22-84822; Editor assigned: 06-Dec-2022, PreQC No. AACOCR-22-84822(PQ); Reviewed:15-Dec-2022, QC No. AACOCR-22-84822; Revised:24-Dec-2022, Manuscript No. AACOCR-22-84822(R); Published: 29-Dec-2022, DOI:10.35841/aacocr-5.6.129
Citation: Babo P. A study of current chemotherapeutic methods for treating humans. J Clin Oncol Cancer Res. 2022; 5(6):129
AbstractThe treatment of disease by immune system activation or suppression is known as immunotherapy or biological therapy. Immunotherapies that lower or suppress the immune response are referred to as suppression immunotherapies, whereas immunotherapies that activate or amplify the immunological response are referred to as activation immunotherapies.
Chemotherapy, Resistance, Control.
The potential of immunotherapy to treat different types of cancer is the subject of preliminary investigation. For some malignancies, cell-based immunotherapies are effective. Targeting aberrant antigens produced on the surface of tumour cells, immune effector cells such lymphocytes, macrophages, dendritic cells, natural killer cells, and cytotoxic T lymphocytes cooperate to protect the body from cancer. Immunization against COVID-19 is largely mediated by an immunomodulatory T cell response.
Medical usage has been granted to treatments like Granulocyte Colony-Stimulating Factor (G-CSF), interferons, imiquimod, and bacterial cellular membrane fractions. Clinical and preclinical research also involve other substances, such as glucans, synthetic Cytosine phosphate-Guanosine (CpG) oligodeoxynucleotides, IL-2, IL-7, and IL-12, as well as other chemokines .
Chemotherapy, surgery, or radiation was once the main methods of cancer treatment used to eradicate or remove cancerous cells and tumours. These treatments can be quite successful and are still often utilised. James P. Allison and Tasuku Honjo received the 2018 Nobel Prize in Physiology or Medicine for their discovery of cancer therapy through inhibition of negative immune regulation. The goal of cancer immunotherapy is to activate the immune system to eliminate tumours. Many other tactics are in use or are being investigated and tested. Cell-based immunotherapy's efficacy is increased by 20–30% when paired with traditional treatment options, according to randomised controlled studies in various tumours that showed a significant increase in survival and disease-free period .
The BCG vaccination, which was initially developed to prevent tuberculosis but is now used to treat bladder cancer, is one of the earliest types of cancer immunotherapy. Both local and systemic immune responses are brought up by BCG treatment. Although extensively researched, the mechanisms by which BCG immunotherapy induces tumour immunity are still not fully known . With the introduction of rituximab, an anti-CD20 antibody for the treatment of B cell lymphoma, monoclonal antibodies were first used in cancer therapy. Since then, a number of monoclonal antibodies have been authorised for use in treating a variety of solid tumours and haematological malignancies .
The removal of G-CSF lymphocytes from the blood, their in vitro expansion against a tumour antigen, and then the subsequent reinjection of the cells with the proper stimulatory cytokines. The tumour cells that express the antigen are then destroyed by the cells. Using an immune-boosting cream (imiquimod), topical immunotherapy kills superficial malignant melanoma, actinic keratoses, basal cell cancer, vaginal intraepithelial neoplasia, squamous cell carcinoma, and warts by activating the recipient's killer T cells .
The majority of the current methods for DC-based vaccination rely on injecting antigen-loaded DCs back into patients after they have been activated with various TLR ligands and cytokine combinations on in vitro-generated DCs from monocytes or CD34+ cells. The in vivo targeting methods include injecting particular cytokines (like Flt3L or GM-CSF) and targeting the DCs with agonistic or C-type lectin receptor-specific antibodies (like anti-CD40) or antibodies that are conjugated with the desired antigen. Future strategies might concentrate on DC subsets with highly expressed C-type lectin receptors or chemokine receptors. Making genetically modified DCs from induced pluripotent stem cells and using neoantigen-loaded DCs to improve clinical outcomes are two other potential strategies.
- Docampo R, Moreno SNCurrent chemotherapy of human African trypanosomiasis. Parasitol Res. 2003;90(1):S10-3.
- Babokhov P, Sanyaolu AO, Oyibo WA, et al.A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis. Pathog Glob Health. 2013;107(5):242-52.
- Burri C. Chemotherapy against human African trypanosomiasis: is there a road to success?. Parasitol. 2010;137(14):1987-94.
- Burchmore RJ, Ogbunude PO, Enanga B, et al. Chemotherapy of human African trypanosomiasis. Curr Pharm Des. 2002;8(4):257-67.
- Lutje V, Seixas J, Kennedy A Chemotherapy for second?stage Human African trypanosomiasis. Cochrane Database Syst Rev. 2013(6).