Journal of Diabetology

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Commentary - Journal of Diabetology (2022) Volume 7, Issue 5

An in depth journey into diabetes mellitus: Causes, symptoms, and treatment

Lynne E Wagenknecht *


Corresponding Author:
Lynne E Wagenknecht
Department of Public Health Sciences,
Wake Forest University School of Medicine, Winston-Salem, NC, USA

Received: 30-Aug-2023, Manuscript No. AADY-23-118321; Editor assigned: 01-Sep-2023, PreQC No. AADY-23-118321(PQ); Reviewed: 15-Sep-2023, QC No. AADY-23-118321; Revised: 19-Sep-2023, Manuscript No. AADY-23-118321(R); Published: 26-Sep-2023, DOI:10.35841/aady-7.5.164

Citation: Wagenknecht L E. An in depth journey into diabetes mellitus: Causes, symptoms, and treatment. J Diabetol. 2023; 7(5):164

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Diabetes mellitus is a global health epidemic characterized by hyperglycemia, resulting from impaired insulin secretion, action, or both. It encompasses a heterogeneous group of disorders, including type 1 diabetes (T1D), type 2 diabetes (T2D), gestational diabetes, and other less common types. In this review, we primarily focus on T1D and T2D. Diabetes mellitus is a chronic metabolic disorder that affects millions of individuals worldwide. This review article provides a comprehensive overview of diabetes mellitus, covering its types, pathophysiology, risk factors, clinical manifestations, diagnosis, and management strategies. With a focus on both type 1 and type 2 diabetes, we explore the latest research developments and emerging therapies to shed light on the current state of knowledge and future directions in diabetes management [1].

Types of Diabetes

Type 1 Diabetes (T1D)

Type 1 diabetes is an autoimmune disease in which the body's immune system mistakenly attacks and destroys insulin-producing beta cells in the pancreas. This results in an absolute insulin deficiency, necessitating lifelong insulin therapy [2].

. The exact cause of T1D remains unclear, but genetic and environmental factors are believed to contribute to its development.


Type 2 Diabetes (T2D)

Type 2 diabetes is characterized by insulin resistance and relative insulin deficiency. It is strongly associated with lifestyle factors, such as poor diet, sedentary behavior, and obesity [3].

. Genetic predisposition also plays a role in T2D risk. Lifestyle modifications and medications are key components of its management.



The pathophysiology of diabetes mellitus varies between T1D and T2D. In T1D, autoimmunity leads to the destruction of beta cells, resulting in the loss of insulin production. In contrast, T2D is characterized by insulin resistance in peripheral tissues, primarily the liver, muscle, and adipose tissue, along with impaired insulin secretion from pancreatic beta cells [4].


Risk factors

Common risk factors for T2D include obesity, physical inactivity, family history, ethnicity, and age. T1D is primarily associated with genetic predisposition and environmental triggers, such as viral infections.

Clinical manifestations

Symptoms of diabetes include increased thirst, frequent urination, unexplained weight loss, fatigue, and blurred vision. Long-term complications can affect various organ systems, leading to cardiovascular disease, retinopathy, neuropathy, nephropathy, and lower limb amputations.


Diabetes is diagnosed based on fasting blood glucose, oral glucose tolerance tests, and HbA1c levels. Early detection is crucial to prevent complications. Management strategies for diabetes mellitus involve lifestyle modifications, pharmacotherapy, and, in some cases, insulin therapy [5].



Lifestyle modifications

Diet: A balanced, low-carbohydrate, and low-sugar diet can help control blood glucose levels.

Exercise: Regular physical activity improves insulin sensitivity.

Weight management: Achieving and maintaining a healthy weight is essential for T2D management.


Oral Medications: Various classes of oral medications are available for T2D.

Insulin: T1D and some cases of T2D require insulin therapy.

Emerging therapies

Recent advances in diabetes research have led to innovative therapies, including continuous glucose monitoring, artificial pancreas systems, and incretin-based medications. Stem cell therapy and gene editing techniques also show promise for T1D.


Diabetes mellitus is a complex and prevalent metabolic disorder that requires a multidisciplinary approach for effective management. Advances in research and therapy offer hope for improved outcomes and a better quality of life for individuals living with diabetes. A holistic approach, including early diagnosis, patient education, and ongoing support, is essential in the battle against diabetes. This review highlights the importance of understanding the types, pathophysiology, risk factors, clinical manifestations, diagnosis, and management strategies related to diabetes mellitus, with a particular focus on the ever-evolving landscape of research and therapies in this field.


  1. Clayton Jr W, Elasy TA. A review of the pathophysiology, classification, and treatment of foot ulcers in diabetic patients. Clin Diabetes. 2009;27(2):52-8.
  2. Indexed at, Google Scholar, Cross Ref

  3. Lipsky BA, Berendt AR, Cornia PB, et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54(12):e132-73.
  4. Indexed at, Google Scholar, Cross Ref

  5. Lipsky BA. Medical treatment of diabetic foot infections. Clinical Infectious Diseases. 2004;39(Supplement_2):S104-14.
  6. Google Scholar, Cross Ref

  7. Lipsky BA. Medical treatment of diabetic foot infections. Clinical Infectious Diseases. 2004;39(Supplement_2):S104-14.
  8. Google Scholar, Cross Ref

  9. Cooper GJ. Therapeutic potential of copper chelation with triethylenetetramine in managing diabetes mellitus and Alzheimer’s disease. Drugs. 2011;71:1281-320.
  10. Indexed at, Google Scholar, Cross Ref

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