Journal of RNA and Genomics

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Research Article - Journal of RNA and Genomics (2021) Volume 17, Issue 0

Upregulation of SLC11A1 is associated with poor survival in head and neck cancer patients

SLC11A1 upregulation has a significant impact on cancer development and metastasis. Several studies have found the upregulation of SLC11A1 associated with tumorigenesis and poor survival in patients with cancer. However, the expression and prognostic value of SLC11A1 remain largely unknown in HNSCC. The present study aimed to analyze the expression of SLC11A1 is associated with prognosis in HNSCC. In the present study, we used the large TCGA (The Cancer Genome Atlas) RNA sequencing (RNAseq) dataset to explore the SLC11A1 expression level in HNSCC. This study included a total of 564 tissue samples (520 samples from HNSCC and 44 as control tissues). The mRNA expression level of SLC11A1 in various kinds of cancers, including HNSCC, was analyzed via the UALCAN database. The mRNA expression level of SLC11A1 was increased in most cancers compared with normal tissues, especially in HNSCC. Besides, we also used a Kaplan-Meier plotter to evaluate the prognostic value of SLC11A1 in HNSCC patients. It showed highly expressed SLC11A1 was significantly related to poor Overall Survival (OS) in HNSCC patients. The SLC11A1 is highly expressed in HNSCC and associated with poor survival in HNSCC patients. Therefore, SLC11A1 could be a promising prognostic biomarker for HNSCC.

Author(s): Aleena A, Smiline Girija AS, Balachander K, Vijayashree Priyadharsini J, Arumugam Paramasivam

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