Journal of Diabetology

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Research Article - Journal of Diabetology (2024) Volume 8, Issue 1

Thrombotic Trends: Investigating Mean Platelet Volume in Type 2 Diabetes Mellitus

Platelet activity is a crucial factor in the pathogenesis of vascular complications in diabetes. Mean platelet volume (MPV) has been proposed as a marker of platelet reactivity and is associated with various vascular risk factors. This study aimed to investigate the association between MPV and glycemic control as indicated by HbA1c levels and the role of MPV as a predictor of vascular complications in diabetic patients. Methods: A cross-sectional analysis was conducted on 100 diabetic patients and 100 non-diabetic controls. Diabetic patients were stratified into two groups: HbA1c <6.5% and HbA1c ≥6.5%. MPV and platelet count was measured for all participants using an automated blood cell counter. Statistical analysis was performed by using SPSS using Student’s t test and Pearson correlation test. Results: MPV was significantly higher in diabetics than non-diabetics (13.41±0.44 fl vs 12.29±0.0.53 fl: p=0.0001) as well as in diabetics with HbA1c ≥6.5% than those with HbA1c <6.5% (13.65±0.44 fl vs 12.93±1.79fl; p<0.0068). However, the mean platelet count did not show a statistically significant difference between diabetics and non- diabetics as well as the two HbA1c groups. Diabetics with vascular complications exhibited significantly higher MPV (13.6±0.47 fl) compared to those without vascular complications (13.21±0.32 fl; p<0.0001) . Conclusion: Our study suggests a significant association between glycemic control, MPV and vascular complications in diabetic patients. These findings underscore the importance of maintaining glycemic control to mitigate platelet hyperactivity as well as the role of MPV as a predictor of diabetes-related vascular complications.

Author(s): Dutta Anupam, Saikia Projnon, Sarma Kalyan, Devi Bhanu

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