Biomedical Research

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- Biomedical Research (2010) Volume 21, Issue 1

The prototype of Desmosomal junctions? proteins during embryonic development of ecodermal derived organ

During development, mammary gland epithelium goes through long and complicated devel-opmental process that involves proliferation, migration and morphological restructuring. Desmosomal junctions have been linked to these crucial developmental events. In this study the change in the desmosome and hemidesmosome during mammary gland development was examined through examining desomosmal proteins expression pattern using immuno-histochemistry and electron microscopy techniques. The results support the suggestion that desmosomes and hemidesmosomes are remodelled during mammary gland development. It also suggests that early mammary gland develop-ment stages, the cells require stronger adhesive mechanisms than at later stages. Such physical support is maintained by the desmosomes that hold the cells in the centre of the growing cells of developing mammary gland.

Author(s): M. Alfayez

Abstract Full Text PDF

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