Current Pediatric Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44 1400 530055

Research Article - Current Pediatric Research (2019) Volume 23, Issue 2

Study of Vitamin D and melatonin supplementation as adjuvant therapies in neonatal jaundice

Background: Neonatal jaundice is a common problem in neonates which is treated by various methods to avoid the development of complication especially bilirubin encephalopathy or kernicterus.

Patient and methods: This is a prospective clinical trial was done from July 2016 to January 2018 in Tanta University Hospital on 150 neonates suffering from neonatal jaundice. The studied neonates were divided into 3 Groups: Group 1 who was treated by vitamin D and phototherapy, Group 2 who were treated by melatonin and phototherapy and Group 3 who were treated by phototherapy alone.

Results: The serum bilirubin was significantly declined in neonates of group 1 who were treated by vitamin D and phototherapy, compared with neonates of Group 2 and 3 who were treated with combined melatonin with phototherapy and phototherapy, respectively with p-value equal 0.009* and 0.001* respectively. There was a significant decrease in serum bilirubin levels in neonate of Group 2 who was treated with melatonin and phototherapy if compared with Group 3 who was treated by phototherapy alone with p-value equal 0.003*.

Conclusion: Vitamin D and melatonin could be used as adjuvant therapies in neonatal jaundice in combination with phototherapy with superiority of vitamin D over melatonin.

Author(s): Mohamed Shawky Elfarargy*, Dina Adam Ali, Ghada Mohammad Al-Ashmawy

Abstract Full Text PDF

Get the App