Journal of RNA and Genomics

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Research Article - Journal of RNA and Genomics (2021) Volume 17, Issue 0

Studies on the N-nitrosodiethylamine induced changes in the cell cycle regulatory protein in the liver of adult male express: therapeutic role of diosmin.

Diosmin, a flavonoids rich in citrus fruits, are plant derived dietary polyphenols with natural antioxidant properties. Diosmin inhibits pro apoptotic activator as a chemo prevent agent thus acts as a promising anticancer agent. The effect of diosmin in the expression of cell cycle regulatory protein, such as cyclin D1 and cyclin D4 in NDEA induced experimental animals were studied. The study concludes that diosmin has an anticancer effect against NDEA induced experimental HCC by modulating the expression of cell cycle regulatory proteins and thereby reveals the anti-carcinogenic potential of diosmin can be used as future therapeutic agents against liver cancer. The effect of diosmin in the expression of cell cycle regulatory protein, such as cyclin D1 and cyclin D4 in NDEA induced experimental animals were studied. Male Wistar albino rats were divided into 3 groups. Group 1: Normal control, Group 2: NDEA induced rats (for 16 weeks), Group 3: NDEA induced rats treated with diosmin (for 28 days). The data were analysed statistically by a one way Analysis of Variance (ANOVA) followed by Duncan’s multiple range test was used to see the statistical significance among the groups. The results with the p<0.05 level were considered to be statistically significant. The hepatocellular induced rats show significant increase (p<0. 05) in mRNA expressions of cyclin D1 and D4 in the liver compared to control rats. The study concludes that diosmin has an anticancer effect against NDEA induced experimental HCC by modulating the expression of cell cycle regulatory proteins and thereby reveals the anti-carcinogenic potential of diosmin can be used as future therapeutic agents against liver cancer.

Author(s): Akshetha LS, Gayathri R, V Vishnu priya, J Selvaraj, Kavitha S

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