Journal of Clinical Nephrology and Therapeutics

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Abstract - Journal of Clinical Nephrology and Therapeutics (2020) Volume 0, Issue 0

Something new, something good. MCU - Medium Cut-off filter for COVID - 19 AKI : First use in Ecuador

This article evidences the effectiveness of the use of MCO filters in the removal of IL-6 in a patient with acute renal failure caused in a critically ill patient with COVID-19 who need renal replacement therapy in continuos venvenous hemodialysis modality. COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and serves as an independent risk factor for all-cause in-hospital death in patients with COVID-19 1,2. MCO membranes allows to remove middle molecules (50,000 Da), such as IL-6, IL-1, FNT-a, FLC k (aorund 25000 Da)3, proteins associated with the inflammatory responsethis. MCO has the ability may reduce inflammation, as supported by the lowering of the concentration of inflammatory cytokines and the reduction of transcription of proinflammatory cytokines in peripheral leukocytes4.


Author(s): Harold Alvarez, Victor Ortega

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