Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 504 6082390

Research Article - Biomedical Research (2017) Volume 28, Issue 3

Serum CEA, CA125, CA19-9, and CA724 levels for the diagnosis and staging of cholangiocarcinoma

Background: Aims serum markers provide a non-invasive, cheap and effective diagnostic and prognostic tool for cholangiocarcinoma. In this study, we aimed to evaluate serum levels of CEA, CA125, CA19-9 and CA724 for the diagnosis and staging of cholangiocarcinoma.

Materials and Methods: Serum levels of CA125, CA19-9, CA724 and CEA were measured preoperatively, postoperatively and during follow-up in 153 cases of cholangiocarcinoma and 65 cases of benign biliary disease.

Results: Serum levels of these tumor markers elevated in cholangiocarcinoma, and CA19-9 was better than CEA, CA125, CA724 or the combination to diagnose cholangiocarcinoma with the cut off value of 73.25 U/ml (sensitivity 69.30%; specificity 87.7%). Serum CA125 and CA19-9 levels were helpful to assess advanced TNM stage.

Conclusion: Serum CA19-9 level is superior to CEA, CA125 or CA724 levels or the combination for the diagnosis of cholangiocarcinoma. Preoperative serum levels of CA19-9 could be used to predict advanced TNM stage and evaluate the resectability of cholangiocarcinoma.

Author(s): Yawen Deng, Rihui Zhong, Xiaoying Xie, Xuxia Xiong, Jian He, Linhui Peng, Hua Zeng, Chaohui Duan

Abstract Full Text PDF