Case Report - Current Pediatric Research (2025) Volume 29, Issue 2

Prolonged Inhaled Nitric Oxide Treatment for 25 weeks Gestation Extreme Preterm with Persistent Pulmonary Hypertension

Persistent Pulmonary Hypertension of the Newborn (PPHN) is characterized by high pulmonary vascular resistance, leading to right-to-left shunting of blood and resultant hypoxemia. Inhaled Nitric Oxide (iNO) has been widely used for managing PPHN in term and near-term neonates, but its role in extremely preterm infants remains less clear. While trials of iNO in Very Low Birth Weight (VLBW) infants suggest its safety, the efficacy, optimal duration of treatment and the possibility of using it with noninvasive ventilation in extremely preterm infants with PPHN are areas of ongoing research. This case study highlights the use of a prolonged course of inhaled nitric oxide (including both invasive and noninvasive ventilation) in an extremely preterm neonate with severe PPHN, as well as the challenges encountered during treatment

Author(s):

Salem Deraz, Somar Alhourany, Yasser El Gohary*, Reem Mahmoud Suliman, Olfat Alzaabi,
Mohamed Ali Kasem Hussien Eleimy, Basel Aoun, Mahmoud Allam, Luay Abdalwahab, Ribal Kasem

Abstract PDF