Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1-504-608-2390

- Biomedical Research (2011) Volume 22, Issue 4

Prevalence of inducible Clindamycin resistance among community-and hospital-associated Staphylococcus aureus isolates in a tertiary care hospi-tal in India

Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that include resistance to macrolide, lincosamide and strepto-gramin antibiotics. In vitro routine tests for clindamycin susceptibility may fail to detect inducible clindamycin resistance thus necessitating the need to detect such resistance by a simple D test on routine basis. Among 446 clinical isolates of Staphylococci studied, 145(32.5%) were MRSA and 301(67.84%) were MSSA. Of the 446 staphylococcal isolates 87 (19.50%) were resistant to erythromycin of which 41 (47.12%) showed inducible clindamycin resistance and belonged to the MLSBi phenotype. Among the 41 MLSBi phenotype 36(87.80%) were MRSA and 5(12.19%) were MSSA. Of the 36 MRSA 9(25%) were CA-MRSA and 27 (75%) were HA-MRSA. We conclude therefore, that D-test should be used as a mandatory method in routine disc diffusion testing to detect inducible Clinda-mycin resistance.

Author(s): Jadhav Savita Vivek, Gandham Nageswari Rajesh, Sharma Mukesh, Kaur Manpreet, Misra R.N. , Matnani G.B. , Ujagare M.T., B. Saikat, Kumar Ajay

Abstract Full Text PDF

Get the App

https://pmasites.com