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Opinion Article - Journal of Cholesterol and Heart Disease (2022) Volume 6, Issue 5
Mechanism of familial hypercholesterolemia during childhood genetic diagnosis
One of the most prevalent illnesses that doctors encounter is hypercholesterolemia. It continues to be one of the main modifiable cardiovascular risk factors, and significant improvements in risk classification techniques and viable treatment choices have been made. The development of Peripheral Vascular Disease (PVD) and Coronary Artery Disease (CAD) have been repeatedly linked to total cholesterol levels above 200 mg/dl and much attention has been paid to evaluating the mechanisms by which hypercholesterolemia may affect these outcomes. It has been clearly illustrated that the progression of hypercholesterolemia is linked to endothelial cell dysfunction, a near total loss of vascular nitric oxide bioavailability, increased oxidative stress, and the development of a strongly pro-inflammatory condition; symptoms that can result in significant impairments/alterations to vascular reactivity.
Author(s): Mafalda Bourbon