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Opinion Article - Journal of Pharmaceutical Chemistry & Chemical Science (2022) Volume 6, Issue 2
Licensing hydrogels encased mesenchymal stromal cells.
Gene therapy is a new field of science that uses stem cells as a cell-based therapy to regenerate and restore injured tissue. Stem cells have the ability to self-renew and differentiate into specific lineages, making them a good backup reservoir in the event of tissue damage. They can be autonomously or allogeneically transferred for tissue regeneration in a therapeutic setting; however, allogeneic stem cell transplant can trigger host immunological responses, resulting in a host-versus-transplant reaction. Stem cell encapsulation, a process that encases stem cells in a semi-permeable membrane made of diverse biomaterials, is a possible answer to this problem. Stem cell encapsulation can be achieved using a wide range of natural and synthetic hydrogels, and it has a number of advantages in regenerative medicine, including protection from the protective immune response and mechanical stress, improved cell viability, proliferation, and differentiation, cryopreservation, and controlled and continuous delivery of stem-cell secreted therapeutic agents. We report and evaluate almost all organic and inorganic hydrogels used in stem cell encapsulation in this study, as well as the potential benefits which these materials, alone or in combination, could provide to cell treatment through functional cell encapsulation.
Author(s): Ferntongo Ancey*