Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

- Biomedical Research (2016) Volume 27, Issue 2

Intrarenal angiotensin II plays an important role in renal fibrosis in primary IgA nephropathy.

Objective: To investigate the relationship of intrarenal angiotensin II (Ang II) expression with clinicpathological injury index and intrarenal expression and regulation of RAS (renin-angiotensin system) components in IgAN (immunoglobulin A nephropathy) patients.

Material and methods: The expression of intrarenal renin, angiotensinogen (AGT), Ang II, Ang IIreceptor was examined by immunohistochemistry staining (IHCS). Clinic-pathological injury index included blood pressure, estimated glomerular filtration rate (eGFR), proteinuria and Katafuchi score.

Results: Positive IHCS area of intrarenal Ang II was 32.73 ± 14.74%. There was a negative correlation between intrarenal Ang II and eGFR (r=-0.61, P<0.01), index of glomerular hypercellularity (ρ=-0.35, P<0.05).Intrarenal Ang II correlated positively with pathological chronicity index (ρ=0.39, P<0.05), index of interstitial cell infiltration (ρ=0.52, P<0.01), index of tubular atrophy (ρ=0.51, P<0.01), index of vessel wall thickening (ρ=0.36, P<0.05) and index of arteriolar hyalinosis (ρ=0.36, P<0.05). Intrarenal Ang II positively correlated with intrarenal renin and AGT (r=0.43, P<0.01 and r=0.3, P<0.05, respectively). No other correlation was evidenced between intrarenal expression of explored RAS components.

Conclusions: Intrarenal Ang II plays an important role in renal fibrosis in IgAN, particularly at the tubulointerstitial level. Moreover, there is a tight regulation of the intrarenal RAS components in IgAN.

Author(s): Han Wen-lun, Zhu Yun-yun, Zhong Yu, Ding Hui-deng

Abstract Full Text PDF

Get the App