Biomedical Research

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- Biomedical Research (2016) Volume 27, Issue 1

Intestinal oxidative damage and mucin regulated gene response to Plasmodium chabaudi malaria infection.

Malaria, initiated inevitably by examining those apicomplexan parasites Plasmodium, is a huge purpose behind horribleness likewise mortal adversary all around the world particularly in developing countries. The current study aimed to investigate the mice intestinal oxidative damage and mucin regulated gene response to Plasmodium chabaudi infection. The infection of female C57BL/6 mice with 106 P. chabaudi parasitized erythrocytes induced a maximum parasitemia (about 47 %) on day 8 p.i.. Histological examination of stained sections showed some defects in jejunal tissue of mice infected with P. chabaudi were injured and contained marked inflammatory cells. In addition, examination of Alcian blue stained sections demonstrated a significant increase in the number of goblet cells of the jejunal villi. Moreover, the infection induced a significant increase in the level of NO and MDA while the level of GSH was significantly decreased by the infection. Upon infection with P. chabaudi, there was a significant increase in the mRNA expression of MUC2 and MUC4. Based on our results, we can conclude that, the intestinal response to P. chabaudi infection could help in understanding the process of intestinal oxidative damage as well as the role of mucin related genes during infection. Further studies are required to know the mechanism and the pathway by which the parasite induce these intestinal alteration

Author(s): Mohamed A Dkhil, Denis Delic, Saleh Al-Quraishy

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