Journal of Systems Biology & Proteome Research

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Rapid Communication - Journal of Systems Biology & Proteome Research (2022) Volume 3, Issue 2

In the flesh scoparia dulcis has a protective effect on the liver, kidney, and brain

The researchers wanted to see how an aqueous extract of Scoparia dulcis affected the occurrence of oxidative stress in the brains of diabetic rats by evaluating the level of oxidative damage and the antioxidant defence system. The effect of an aqueous extract of the Scoparia dulcis plant on blood glucose, plasma insulin, and the levels of thiobarbituric acid reactive substances (TBARS), hydroperoxides, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and reduced glutathione (GSH) in diabetic rats induced with the standard reference medication was glibenclamide. Plasma insulin, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, and reduced glutathione activity all increased significantly in brain on treatment with body weight of Scoparia dulcis plant extract (SPEt) and glibenclamide. Both treated groups had significantly lower levels of TBARS and hydroperoxides in the brain, implying that it may have a role in protecting against lipid peroxidation-induced membrane damage. These findings point to a putative antiperoxidative role for Scoparia dulcis plant extract, as activation of antioxidant enzymes is regarded a trustworthy marker for evaluating the antiperoxidative performance of medicinal plants. Scoparia dulcis, in addition to having an anti-diabetic effect, also has antioxidant properties that could be used for therapeutic purposes.

Author(s): Hasan Abosbah

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