Mini Review - Journal of Medical Oncology and Therapeutics (2022) Volume 7, Issue 6
Illustrative focus with respect to endocrine resistance in breast cancer and clinical pathology highlights.
The pro-proliferative effects of oestrogens are well characterized and there is a growing body of evidence to also suggest an important role in tumorigenesis. Importantly, obesity not only increases the risk of breast cancer, but it also increases the risk of recurrence and cancer-associated death. Aromatase is the rate-limiting enzyme in estrogenic biosynthesis and its expression in breast adipose stromal cells is hypothesized to drive the growth of breast tumours and confer resistance to endocrine therapy in obese postmenopausal women.Author(s): Haruki Tanaka*