Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

Research Article - Biomedical Research (2021) Volume 32, Issue 2

Hypoglycemia and neurological outcome in neonates: A retrospective study in a tertiary care hospital in Henan, China

This is a retrospective study done on 170 children, aged 3 to 5 years, who were delivered in the third affiliated hospital of Zhengzhou university, Henan, China between Jan 2019 to Dec 2020. With the help of hospital records, a systematic detection of hypoglycemia (<2.2 mmol/L or 40 mg/dL) was carried out in the study population from birth to 28 days after birth. Main outcomes were a compiled neurological or neurodevelopmental outcome; any developmental delay; motor developmental delay; and cognitive developmental delay. For analysis, the study population was divided into two groups: one group consisted of children who suffered from 5 or more episodes of hypoglycemia in neonatal period (n=42) and the second group consisted those who suffered with less than 5 episodes (n=128). We noted that the group having 5 or more hypoglycemic episodes had a higher proportion of premature or small for date children than the other group (76.2% Vs 60.9%), and the difference is statistically significant. In adjusted regression analyses, the odds ratio (OR) of any neurological or neurodevelopmental outcome was 1.48 (95% confidence interval: 1.17–1.88) in group with 5 or more hypoglycemic episodes as compared to the other group. The adjusted risk of any developmental delay was more than doubled (OR 2.53 [1.71–3.73]), the adjusted risk of motor developmental delay was almost doubled (OR: 1.91 [1.06–3.44]) and the adjusted risk of cognitive developmental delay was almost tripled (OR 2.85 [1.70–4.76]) in the group that had more than 5 hypoglycemic episodes in neonatal period.

Author(s): Mohammad Shakir Hussain Ansari, Xiao Li, Xiaoli Zhang, Kaixian Du, Yan Dong, Xiaoli Li, Qiliang Guo,Ling Gan, Tianming Jia

Abstract Full Text PDF

Get the App