Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1-504-608-2390

- Biomedical Research (2016) Volume 27, Issue 2

Hyperhomocysteinemia in human immunodeficiency virus-infected patients.

Objective: Evaluation of Hyperhomocysteinemia (HHCY) in HIV-infected patients.

Methods: Retrospective cohort study of risk factors for HHCY (>14 mmol/L) in patients infected with HIV for more than three years and treated, or not, with different combinations of HAART. Eighty cases were selected for this study.

Results: 46.3% (n=37) of HIV infected have HHCY. Hepatitis B or C co-infection and lower levels of Total Antioxidative System (TAS) are the most important factors associated with HHCY (OR=3.2, p=0.021 and OR=63.9, p=0.027, respectively). Although not statistically significant, the HHCY individuals have more cases of overweight and obesity, IP HAART scheme, lipodystrophy, and higher levels of Homa index. The sample with 2 criteria for Metabolic Syndrome (MS) and with MS, has significantly higher mean values of HCY compared to those without MS group.

Conclusions: The presence of hepatitis B or C co-infection and lower levels of TAS are the most important factors associated with HHCY in a group of patients infected with HIV, with or without HAART. Within this group, those with 2 criteria for SM or with SM have higher values of HCY.

Author(s): Duro M, Manso MC, Rebelo I, Medeiros R, Almeida C

Abstract Full Text PDF

Get the App