Conference Proceedings - Gynecology and Reproductive Endocrinology (2021) Volume 5, Issue 0

High risk of developing cancer in young patients with fanconi anemia

Background: Fanconi anemia (FA) is a genetic disorder, autosomal recessive or linked to the X chromosome, which presents with pancytopenia, congenital malformations and predisposition to develop cancer. Methods: We present the case of a 20-year-old female patient with Fanconi Anemia who developed gynecological and hematological neoplasms that were treated with surgery, radiotherapy and chemoterapy treatment in a limited manner due to the toxicity presented. Results: The patient developed vulvar cancer and multiple clinical complications that prevented the application of full treatment leading to a fatal outcome. Conclusions: Individuals with FA are at increased risk for a number of solid tumors and this risk is likely to be increased in those who have undergone hematopoietic cell transplantation (HCT). Routine cancer screening and preventive interventions eg, human papilloma virus (HPV) vaccination must be recommended. If a patient with FA develops a malignancy that requires chemotherapy and/or radiation therapy, dose reductions or alternative regimens are likely to be necessary. Keywords: Fanconi anemia, pancytopenia, vulvar carcinoma, acute myeloblastic leukemia

Author(s): Paloma Ortega Quiñonero

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