Research Article - Journal of RNA and Genomics (2021) Volume 17, Issue 0

High expression of NCF2 is associated with poor survival in patients with head and neck squamous cell carcinoma.

Background and aim: NCF2 expression has a significant impact on cancer development and progression. Several studies have found the increased expression of NCF2 associated with tumorigenesis and poor prognosis in patients with cancer. However, the expression and prognostic value of NCF2 remain largely unknown in HNSCC. Objective: The present study aimed to analyze the expression and prognostic value of NCF2 in HNSCC. Materials and methods: In the present study, we used the large TCGA (The Cancer Genome Atlas) RNA sequencing (RNAseq) dataset to explore the NCF2 expression level and its prognostic value in HNSCC. The mRNA expression level of NCF2 in various kinds of cancers, including HNSCC, was analyzed via the UALCAN database. Results: We observed that the mRNA expression level of NCF2 was increased in most cancers compared with normal tissues, especially in HNSCC. Also, we also used Kaplan-Meier plotter to evaluate the prognostic value of NCF2 in HNSCC patients. It showed highly expressed NCF2 was significantly related to poor Overall Survival (OS) in HNSCC patients. Conclusion: The NCF2 is highly expressed in HNSCC and associated with poor prognosis in HNSCC patients. Therefore, NCF2 could be a promising prognostic biomarker for HNSCC.

Author(s): Sai Charan L, Arumugam Paramasivam, Smiline Girija AS, Balachander K, Vijayashree Priyadharsini J

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