Journal of RNA and Genomics

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Research Article - Journal of RNA and Genomics (2021) Volume 17, Issue 0

Genetic alterations in Cullin family of genes and their putative association with HNSCC.

The present study was conducted to analyse the mutations in Cullin genes and to determine their possible association with HNSCC. HNSCC comprises a heterogeneous group of malignancies predominantly affecting the squamous epithelium of the head and neck due to factors such as tobacco use and genetic mutations. Alterations in specific genes affect the encoded protein resulting in malignant transformation of normal cells. Identifying such alterations in genes could aid in early detection and diagnosis of HNSCCs. The Cullin family consists of eight genes which work in a cascade mechanism. The oncoprint data obtained after producing the query showed frequency distribution of gene mutations. These mutations were further analyzed using the gnomAD database, to identify mutations which are already reported and those which are novel.

Author(s): Kaviyaselvi Gurumurthy, J Vijayashree Priyadharsini, AS Smiline Girija, P Sankar Ganesh

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