Research Article - Journal of RNA and Genomics (2022) Volume 0, Issue 0
Formulation and Evaluation of Ciprofloxacin Mixed-Micelle Micro particles.
Ciprofloxacin is a fluoroquinolone antibiotics that is available in different dosage forms for the treatment of various forms of bacterial infections. In this study we developed mixed micelles microcapsule formulation consisting of ciprofloxacin (CIPRO) targeted at enhanced antimicrobial, pharmacokinetic and pharmacodynamic properties for improved patient compliance. Gradedconcentrations of ciprofloxacin (0.0, 0.25, 0.5, 0.75 and 1.0 g) dissolved in Transcutol (11 mL) and Phospholipon 90 G (P90 G, 10 g) nanostructured lipid carrier to which the aqueous-phase enriched mixed micelles (Solutol and Poloxamer 118, P118) were added at same temperature (85°C) and subjected to high shear hot homogenization (24 × 1000 rpm for 10 min), before cooling to room temperature were prepared. The resultant microcapsules were characterized by % yield, encapsulation efficiency, particle size, pH storage stability, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and antimicrobial drug release study.Author(s): Nnamani PO, Eze C O, Ani NH, Ozioko CA, Ugwueze M E, Ugwu A A, Kola Mustapha AT