Gynecology and Reproductive Endocrinology

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Short Article - Gynecology and Reproductive Endocrinology (2020) Volume 4, Issue 4

Female Hermaphroditism and Term Pregnancy: About a Case at the National Hospital of Pikine and Review of Literature

This case report, it’s about a patient I met during prenatal consultation, she was in the 2nd semester of her pregnancy, exactly at
25 weeks. During the physical examination, we found, she had a hypoplasia of minor labia, an incomplete vaginal diaphragm with
a vaginal cup, and a hypertrophy of clitoris. We decide to make some biological and instrumental examinations. After getting the
result, we concluded she has a pseudo hermaphroditism associated with malformation of 1/3 of vagina. Reason why the way of the
delivery choose was a C-section.
Female pseudo hermaphroditism is the most frequent (FPH) sexual ambiguity. It is characterized by the extension of abnormality of
the sexual differentiation during the fetal life in the female fetus by a maternal or fetal hyper-genesis. The authors propose through
a clinical case with a patient 46XX DSD pregnant. The main cause of this pathology is congenital adrenal hyperplasia, which we
lead to deficits of 21-hydoxylase, 11-beta-hydroxylase, 3-beta-hydroxysteroid dehydrogenase, but 95% of the congenital adrenal
hyperplasia is the deficiency of 21-hydoxylase. The treatment of congenital adrenal hyperplasia depend of the cause, hormone
replacement therapy like (dexamethasone, hydrocortisone), most often the treatment for life is needed. From this we propose to
make review of literature focusing on it.
Conclusion: The pseudo female hermaphroditism is the most frequent affection of sexual ambiguities, when it is associated with a
pregnancy as in this clinical case, the interest is even greater. From a practical point of view, the etiological diagnosis procedure must
begin with a clinical examination of anomalies of external genital development, a karyotype and a hormone balance (17- hydroxyprogesterone).
The management is multidisciplinary combining medical, surgical, and psychological treatment, and the patient may

decide to undergo surgery later for clitoridoplasty. 

Author(s): Taliana Stephie Gondjout

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