Review Article - Journal of Dermatology Research and Skin Care (2025) Volume 10, Issue 1

Exploring the Role of Hormones in Skin Health and Care â?? A Systematic Review

This systematic review aims to identify the impact of hormones on the skin and explores the dermatological consequences of hormonal abnormalities. For the present systematic review, articles focused on the effect of hormones on acne, aging, xerosis, and hyperpigmentation are considered. Articles on the therapeutic use of hormones are excluded from the present review. 119 prominent dermatology and medical journals were scrutinized for relevant references published from January 1, 2012, to December 2022. We mitigated bias by selecting references with strong methodologies, including detailed study design, clinical parameters, and rigorous statistical analysis. High-impact factors further supported the credibility of these sources. Among the 4628 articles identified, 123 were considered relevant; of these, 79 articles were research studies and 44 were review articles. Research suggests that elevated levels of androgens, IGFs, cortisol, prolactin, and growth hormone, alongside diminished levels of estrogen, melatonin, and PTH, contribute to acne development. Deficiencies in estrogen, androgen, melatonin, vitamin D, MSH, and IGFs and overactivation of cortisol and leptin can result in wrinkles and fine lines. Hyperpigmentation can be triggered by increased levels of MSH, ACTH, and thyroid hormone can be involved, and decreased melatonin and vitamin D. Reduced thyroid hormone levels, estrogen, cortisol, IGF1, and growth hormone can cause xerosis. Of note, hormones like CRH, ACTH, MSH, Growth hormone, Cortisol, Melatonin, and leptin prove to exhibit a circadian behaviour in humans. Recognizing the intricate connections between hormones and skin, professionals can develop more effective and comprehensive skin care strategies to promote overall well-being and beauty

Author(s):

Rossella E. Nappi, Clair Deloche, Gabrielle Sore, Natalia Kovylkina, Elisa Caberlotto, Rachit Singla,
Tarun Kataria, Purva Gado, Christos C. Zouboulis

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