Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1-504-608-2390

- Biomedical Research (2010) Volume 21, Issue 4

Erythrocyte malondialdeyde and antioxidant status in oral squamous cell carcinoma patients and tobacco chewers/smokers

The aim of this study was to evaluate the levels of lipid peroxidation and antioxidants in the erythrocytes of oral cancer patients and tobacco chewers/smokers. 25 patients with biopsy proven oral squamous cell carcinoma(OSCC), 25 cases of tobacco chewers/smokers and 25 age and sex matched healthy control subjects were included in the study. The levels of malondialdehyde (MDA), a lipid peroxidation marker and antioxidants like superoxide dis-mutase(SOD) and glutathione(G-SH) were determined by colorimetric methods. Erythro-cyte MDA levels were significantly increased (p<0.001) and erythrocyte SOD and G-SH lev-els were significantly reduced (p<0.001) in OSCC patients compared to control subjects, where as statistically significant increase(p<0.05) in SOD was observed in tobacco chew-ers/smokers group. There is a negative correlation between MDA and G-SH in OSCC pa-tients and tobacco chewers/smokers. This study shows that there is higher magnitude of oxidative stress in OSCC patients and a weak antioxidant defense system makes the muco-sal cells more vulnerable to the genotoxic effect of reactive oxygen species(ROS). A diet rich in antioxidants may alleviate the oxidative stress to some extent.

Author(s): Raghavendra U, Vivian D? Souza, Benedicta D?souza

Abstract Full Text PDF

Get the App