Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 504 6082390

Research Article - Biomedical Research (2017) Volume 28, Issue 2

Endostr combined with chemotherapy on the advanced digestive tract tumour

Objective: To study the efficacy and side-effect of rh-endostatin injection (YH-16, Endostar), combined with the chemotherapy on the advanced digestive tract tumour.

Methods: 56 patients were divided into two groups, Endostar combined with chemotherapy was administrated to the treatment group (28 cases), and the control group (28 cases) only received chemotherapy.

Results: 56 patients completed two or six cycles. In the treatment group, there were 9 cases achieved PR, 15 cases SD, and 4 case PD; and in the control group, there were 7 cases achieved PR, 14 cases SD, and 7 cases PD. Between the two groups, the Objective Response Rate (PR) were 32.1% (9/28) and 25.0% (7/28), and Disease Control Rate (DCR) were 85.7% (24/28) and 75.0% (21/28) respectively. The Quality Of Life (QOL) between two groups improved on 23 cases (82.1%) and 14 cases (50.0%). The toxicities between two groups showed no significant difference.

Conclusion: The QOL of patients may be improved significantly by endostar combined with chemotherapy and the efficacy was increased, but side effects were not improved.

Author(s): Na Wang, Chao Liu, Xiaojing Hu, Shuting Zheng, Lijun Yang

Abstract Full Text PDF