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Research Article - Asian Journal of Biomedical and Pharmaceutical Sciences (2023) Volume 13, Issue 17
In-vitro evaluation of anticancer potential of vanillin-zinc herbomineral complex.
The anticancer potential of phenolic constituents is mainly attributed to its free radical scavenging activity. However, the poor bioavailability exhibited my most phytoconstituents poses significant constraints for its in-vivo absorption, thereby limiting its anticancer activity. The herbomineral complex of vanillin with zinc was formed using the process of chelation. Zn (II) readily chelates with vanillin to form a stable water soluble vanillin-zinc complex with improved bioavailability. The complex formation was evaluated using UV-Vis spectroscopy, IR, Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), NMR and mass spectroscopy. Vanillin-zinc complex revealed significant improvement in anticancer potential compared with vanillin.
Author(s): Heena Maithania*, S Patil Swati