Research Article - Journal of Pharmaceutical Chemistry & Chemical Science (2021) Volume 5, Issue 3
Effect of fucoxanthin extract from microalgae scenedesmus dimorphus on anti-obesity activity.
Obese people in Indonesia have increased every year. Obesity can lead to other diseases that are harmful to health. Scenedesmus dimorphus microalgae contain carotenoid bioactive compounds, namely fucoxanthin, which are useful as anti-obesity and anti-diabetes. This study aimed to examine the effects of Scenedesmus dimorphus microalgae fucoxanthin extract on lipid metabolism in obese mice fed a High-Fat Diet (HFD). Fucoxanthin extraction was obtained from the microalgae Scenedesmus dimorphus biomass using the ethanol soxhlet extraction method. Male mice aged 8 weeks (30 mice) were divided into 6 groups with normal control, obesity, drug, fucoxanthin extract dose 5; 10; 15 mg/20 g BW, mice induced orally and treated with HFD. Bodyweight and food intake were observed daily and lipid profiles from blood samples were tested every week. The effect of fucoxanthin extract on mice lipid metabolism is decreased levels of total cholesterol, triglycerides, Low-Density Lipoprotein (LDL) and increased levels of High--Density Lipoprotein (HDL), and weight loss of mice. The results of this study indicate the potential of fucoxanthin extract from the Scenedesmus dimorphus microalgae to control obesity as a result of the administration of HFD in vivo.Author(s): Ambar Choirunisa*, Rahmah Aprilian, Nessa Satya Wati, Armaini