Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

- Biomedical Research (2011) Volume 22, Issue 1

Effect of Etoricoxib on fracture healing - An experimental study

Non-steroidal anti-inflammatory drugs (NSAIDs) including selective cyclo-oxygenase-2 (COX-2) inhibitors are some of the most commonly prescribed medications worldwide. Non-selective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of etoricoxib, a new selective COX-2 inhibitor, on bone healing in rabbits, when given in therapeutic doses. Left femur was osteotomized and fixed with K wire in 36 rabbits. One group was fed etoricoxib (3mg/kg body wt/day) orally, while other group served as control. Radiological, morphological, histological and biomechanical analysis of both groups was done at 4, 8 and 12 weeks. An analysis of various parameters of study showed that etoricoxib, a selective COX-2 inhibitor, has significant inhibitory effect on bone healing at 4, 8 and 12 weeks of follow up. So it was concluded that etoricoxib significantly inhibited bone healing in rabbits especially at earlier phases of fracture healing.

Author(s): Ajit Singh, S.K. Saraf, R. S. Garbyal, Shekhar

Abstract Full Text PDF

Get the App