Research Article - Biomedical Research (2017) Volume 28, Issue 20
Effect of combination of amlodipine and ziyin huoxue fang on hypertension patients with coronary heart disease and omentin-1, MMP-3, and TIMP-1 in blood
Objective: To observe the clinical efficacy of combination of amlodipine and Ziyin Huoxue Fang on hypertension patients with coronary heart disease.
Methods: A total of 80 cases of hypertension patients with coronary heart disease were retrospectively collected and sorted into control group and observation group based on various medications, 40 a group. The observation group was given amlodipine and Ziyin Huoxue Fang, while the other group amlodipine only, with a treatment course of eight weeks. All patients were watched for curative effect involving the improvements of blood pressure, angina pectoris, blood fat, serum biochemical indexes, and adverse reaction.
Results: The total effective rate and the marked effective rate of lowering blood pressure and improving angina pectoris in the observation group was significantly better than that of the control group (P<0.05); before treatment, there was no significant difference in blood lipid (TG, TC, HDL-C, and LDL-C), serum Nitric Oxide (NO), Homocysteine (HCY), C Reactive Protein (CRP), omentin-1, MMP-3, and TIMP-1 between two groups (P>0.05). However, after treatment, blood fat (TG, TC, HDL-C, and LDLC), serum HCY, CRP of all patients were greatly decreased and serum NO was significantly increased, and the efficacy of the observation group was better than that of the control group, with a statistical difference (P<0.05). Besides, omentin-1 and TIMP saw a growth but MMP-3 was reduced, and the difference was significant (P<0.05), and compared the control group and observation group, there was statistical difference (P<0.05). About the safety, there was no difference in adverse reactions between two groups (P>0.05).
Conclusion: The combination of amlodipine and Ziyin Huoxue Fang plays a positive role in the treatment of hypertension patients with coronary heart disease, deserving to spread.Author(s): Ma Jing, Zhang Xiaorong