Research Article - Biomedical Research (2017) Volume 28, Issue 18
Dynamic monitoring of serum alpha-fetoprotein and its correlation with early hepatocellular carcinoma in patients with chronic hepatitis B
Objective: To investigate the differences in levels of Alanine Aminotransferase (ALT), HBV-DNA and Alpha-Fetoprotein (AFP) in serum between patients with different clinical types of Chronic Hepatitis B (CHB).
Methods: 274 patients with HBV infection in our hospital from January 2015 to June 2017 were selected and divided into different groups according to various clinical types, including 45 patients in chronic hepatitis B mild group, 62 in chronic hepatitis B moderate group, 58 in chronic hepatitis B severe group, 53 in cirrhosis group and 56 in HCC group. The levels of ALT, HBV-DNA and AFP in serum were detected.
Results: There were significant differences in the levels of ALT, HBV-DNA and AFP in serum between patients in each group (P<0.05). Among them, the serum ALT and HBV-DNA levels in chronic hepatitis B severe group were significantly higher than those in other groups (P<0.05) and the serum AFP level in HCC group was significantly higher than that in other groups (P<0.05). The serum AFP level was positively correlated with the serum ALT and HBV-DNA levels respectively in the patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma (P<0.05). The analysis of receiver operating characteristic curve showed that when ALT<67.65 U/L, HBV-DNA<3.96 IU/Ml, AFP>96.87 ng/L in distinguishing of severe hepatitis, liver cirrhosis and HCC, HCC in patients could be diagnosed preliminary.
Conclusion: The activity and progression of disease in patients with different clinical types of chronic hepatitis B may be known by the levels of ALT, HBV-DNA and AFP in serum, which is helpful for the early diagnosis of HCC.Author(s): Qing-Feng Chen, Xiao-Min Luo, Mei-Ping Zhao, Qi-Hai Wang