Journal of RNA and Genomics

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Review Article - Journal of RNA and Genomics (2021) Volume 17, Issue 0

Diosmin modulates the expression of wnt/β-Catenin mRNA expression in N-Nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in experimental rats.

The current pharmacotherapies associated with cancer are very expensive. Many people cannot afford these drugs which might lead to numerous deaths in the future. The purpose of this study is to find a new potential anticancer herbal drug, which might help in treating cancer. To determine whether diosmin modulates the expression of Wnt/beta catenin mRNA expression in N-nitrosodiethylamine (NDEA)-induced hepato cellular carcinoma in experimental rats. The present result showed that NDEA - induction significantly raised the (p<0.05) mRNA expression of both Wnt and beta catenin in the liver compared to control rats, suggesting that NDEA induces cancer via Wnt/beta catenin signaling. However, diosmin treatment reversed the gene expression of the same (p<0.05) to that of the control.

Author(s): Faaizah Fathima, Gayathri R, V Vishnupriya, J Selvaraj, S Kavitha

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